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Steven E. Shoelson, M.D., Ph.D.

Professor of Medicine
617-732-2528
Publications View
Structure of the IRS-1 PTB domain bound to the juxtamembrane region of the insulin receptor.
Authors: Authors: Eck MJ, Dhe-Paganon S, Trüb T, Nolte RT, Shoelson SE.
Cell
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Evidence for a role for the phosphotyrosine-binding domain of Shc in interleukin 2 signaling.
Authors: Authors: Ravichandran KS, Igras V, Shoelson SE, Fesik SW, Burakoff SJ.
Proc Natl Acad Sci U S A
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Evidence for a physical association between the Shc-PTB domain and the beta c chain of the granulocyte-macrophage colony-stimulating factor receptor.
Authors: Authors: Pratt JC, Weiss M, Sieff CA, Shoelson SE, Burakoff SJ, Ravichandran KS.
J Biol Chem
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Stimulation through the T cell receptor induces Cbl association with Crk proteins and the guanine nucleotide exchange protein C3G.
Authors: Authors: Reedquist KA, Fukazawa T, Panchamoorthy G, Langdon WY, Shoelson SE, Druker BJ, Band H.
J Biol Chem
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Structural basis for IL-4 receptor phosphopeptide recognition by the IRS-1 PTB domain.
Authors: Authors: Zhou MM, Huang B, Olejniczak ET, Meadows RP, Shuker SB, Miyazaki M, Trüb T, Shoelson SE, Fesik SW.
Nat Struct Biol
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Crystal structure of the PI 3-kinase p85 amino-terminal SH2 domain and its phosphopeptide complexes.
Authors: Authors: Nolte RT, Eck MJ, Schlessinger J, Shoelson SE, Harrison SC.
Nat Struct Biol
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4'-O-[2-(2-fluoromalonyl)]-L-tyrosine: a phosphotyrosyl mimic for the preparation of signal transduction inhibitory peptides.
Authors: Authors: Burke TR, Ye B, Akamatsu M, Ford H, Yan X, Kole HK, Wolf G, Shoelson SE, Roller PP.
J Med Chem
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p120cbl is a major substrate of tyrosine phosphorylation upon B cell antigen receptor stimulation and interacts in vivo with Fyn and Syk tyrosine kinases, Grb2 and Shc adaptors, and the p85 subunit of phosphatidylinositol 3-kinase.
Authors: Authors: Panchamoorthy G, Fukazawa T, Miyake S, Soltoff S, Reedquist K, Druker B, Shoelson S, Cantley L, Band H.
J Biol Chem
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Spatial constraints on the recognition of phosphoproteins by the tandem SH2 domains of the phosphatase SH-PTP2.
Authors: Authors: Eck MJ, Pluskey S, Trüb T, Harrison SC, Shoelson SE.
Nature
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Possible v-Crk-induced transformation through activation of Src kinases.
Authors: Authors: Sabe H, Shoelson SE, Hanafusa H.
J Biol Chem
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