BCMP is committed to maintaining excellent and successful research within the department and the Harvard Medical School community by providing state-of-the-art technologies and highly specialized equipment and personnel. Below are the core facilities that either reside or supported by the department.

  • SBGrid
    Director: Piotr Sliz, PhD
    We support structural biologistsby providing structural biology laboratories with a tested and refined software infrastructure that includes a large library of scientific applications. Members also benefit from access to SBGrid-supported high performance computing (HPC) resources andtraining opportunities.
  • Center for Macromolecular Interactions (CMI)
    Director: Kelly Arnett, PhD
    Our mission is to enhance basic research in the department and the HMS community by providing scientific consultation, training and access to shared biophysical equipment for the characterization and analysis of macromolecules and their complexes.
  • Harvard Center for Cryo-Electron Microscopy
    Director: Richard Walsh, PhD
    The Harvard Cryo-Electron Microscopy Center for Structural Biology (HC2EM) is a joint effort by Harvard Medical School, Dana-Farber Cancer Institute, Boston Children’s Hospital, and Massachusetts General Hospital to provide state-of-the-art cryo-EM instrumentation and expertise for the Harvard structural biology community. We are located on the Harvard Medical School campus in the basement of the Seeley G. Mudd building at: Room B04 250 Longwood Avenue, Boston MA 02115.  
    For questions, contact: cryoem@crystal.harvard.edu.
  • Molecular Electron Microscopy Suite (MEMS)
    Director: Zongli Li, PhD
    The Molecular Electron Microscopy Suite at Harvard Medical School is a user resource currently available to qualified researchers affiliated with Quad-based structural biology labs at HMS. This facility offers training and supervision in negative-stain and cryo-transmission electron microscopy of biological samples. Equipment includes four transmission electron microscopes, two cryo plungers, two glow discharge units, and negative stain and cryo sample preparation areas.
    For training and access, contact: cryoem@crystal.harvard.edu or 617-432-7121.
  • Nascent Transcriptomics Core
    Director: Seth Goldman, PhD
    The mission of the NTC is to offer the community a resource for the analysis of nascent transcription, providing new insights into gene regulation and enabling highly sensitive identification of regulatory regions such as enhancers. We offer a streamlined package of services allowing users to submit prepared cells and receive useful analyzed data. We also offer free consultations to discuss experimental and data analysis plans.
    Analysis of nascent RNA--RNA that is actively being synthesized or within minutes of synthesis--can reveal changes in patterns of gene expression, transcription elongation or RNA processing and identify unstable transcripts (such as enhancer RNAs) that are challenging to detect by other RNA sequencing methods.
  • Analytical Chemistry Core
    Director: Michael James
    The Analytical Chemistry Core at HMS provides consultation, training and access to Liquid Chromatography-Mass Spectrometry (LC-MS) instrumentation for the identification and quantitation of small molecules. The core also offers services including method development, data acquisition and analysis across a wide variety of applications.
  • EQNMR Core
    Director: Greg Heffron, PhD
    The East Quad NMR Facility (EQNMR) is a core facility for Bio-molecular NMR spectroscopy. The EQNMR Lab houses state-of-the-art 400, 500, 600, and 700MHz NMR systems capable of conducting multi-dimensional experiments in support of research on structure elucidation of natural products, medicinal chemistry, fragment-based drug discovery, metabolomics, and protein structure and dynamics.

    For a complete list of HMS Core Facilities, please click here.