BCMP is committed to maintaining excellent and successful research within the department and the Harvard Medical School community by providing state-of-the-art technologies and highly specialized equipment and personnel. Below are the core facilities that either reside or supported by the department.
Director: Piotr Sliz, PhD
We support structural biologists by providing structural biology laboratories with a tested and refined software infrastructure that includes a large library of scientific applications. Members also benefit from access to SBGrid-supported high performance computing (HPC) resources and training opportunities.
- Center for Macromolecular Interactions (CMI)
Director: Kelly Arnett, PhD
Our mission is to enhance basic research in the department and the HMS community by providing scientific consultation, training and access to shared biophysical equipment for the characterization and analysis of macromolecules and their complexes.
- Harvard Center for Cryo-Electron Microscopy
Director: Sarah Sterling, PhD
The Harvard Cryo-Electron Microscopy Center for Structural Biology (HC2EM) is a joint effort by Harvard Medical School, Dana-Farber Cancer Institute, Boston Children’s Hospital, and Massachusetts General Hospital to provide state-of-the-art cryo-EM instrumentation and expertise for the Harvard structural biology community. We are located on the Harvard Medical School campus in the basement of the Seeley G. Mudd building at: Room B04 250 Longwood Avenue, Boston MA 02115.
For questions, contact: firstname.lastname@example.org.
- Molecular Electron Microscopy Suite (MEMS)
Director: Zongli Li, PhD
The Molecular Electron Microscopy Suite at Harvard Medical School is a user resource currently available to qualified researchers affiliated with Quad-based structural biology labs at HMS. This facility offers training and supervision in negative-stain and cryo-transmission electron microscopy of biological samples. Equipment includes four transmission electron microscopes, two cryo plungers, two glow discharge units, and negative stain and cryo sample preparation areas.
For training and access, contact: email@example.com or 617-432-7121.
- Nascent Transcriptomics Core
Director: Seth Goldman, PhD
The mission of the NTC is to offer the community a resource for the analysis of nascent transcription, providing new insights into gene regulation and enabling highly sensitive identification of regulatory regions such as enhancers. We offer a streamlined package of services allowing users to submit prepared cells and receive useful analyzed data. We also offer free consultations to discuss experimental and data analysis plans.
Analysis of nascent RNA--RNA that is actively being synthesized or within minutes of synthesis--can reveal changes in patterns of gene expression, transcription elongation or RNA processing and identify unstable transcripts (such as enhancer RNAs) that are challenging to detect by other RNA sequencing methods.
- Analytical Chemistry Core
Director: Bianca Ferreira da Silva, PhD
The Analytical Chemistry Core at HMS offers an Agilent 6530 QTOF LCMS and an Agilent 6130 Single Quad LCMS. This facility is for investigators who can operate these instruments independently after a short training session. Users of the instruments in the Analytical Chemistry Core are expected to run their own samples and interpret the results. The ACC only accepts new users who have some background in analytical chemistry, and have experience running LC-MS.
- Machine Shop
This is a do it yourself shop. Bring your own stock. Remove your own waste. There is a drill press, band saw, mill, and lathe available. If you would like to make arrangements to use the shop please take the shop training and certification course available by clicking here and contact Marie Bao. Machine Shop Safe
Director: Greg Heffron, PhD
The East Quad NMR Facility (EQNMR) is a core facility for Bio-molecular NMR spectroscopy. The EQNMR Lab houses state-of-the-art 400, 500, 600, and 700MHz NMR systems capable of conducting multi-dimensional experiments in support of research on structure elucidation of natural products, medicinal chemistry, fragment-based drug discovery, metabolomics, and protein structure and dynamics.
For a complete list of HMS Core Facilities, please click here.
- Machine Shop