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Steven E. Shoelson, M.D., Ph.D.

Professor of Medicine
617-732-2528
Publications View
Identification and functional characterization of a novel mutation of hepatocyte nuclear factor-1alpha gene in a Korean family with MODY3.
Authors: Authors: Kim KA, Kang K, Chi YI, Chang I, Lee MK, Kim KW, Shoelson SE, Lee MS.
Diabetologia
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Grb10 inhibits insulin-stimulated insulin receptor substrate (IRS)-phosphatidylinositol 3-kinase/Akt signaling pathway by disrupting the association of IRS-1/IRS-2 with the insulin receptor.
Authors: Authors: Wick KR, Werner ED, Langlais P, Ramos FJ, Dong LQ, Shoelson SE, Liu F.
J Biol Chem
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SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2.
Authors: Authors: Rui L, Yuan M, Frantz D, Shoelson S, White MF.
J Biol Chem
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Diabetes mutations delineate an atypical POU domain in HNF-1alpha.
Authors: Authors: Chi YI, Frantz JD, Oh BC, Hansen L, Dhe-Paganon S, Shoelson SE.
Mol Cell
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Crystal structure of the HNF4 alpha ligand binding domain in complex with endogenous fatty acid ligand.
Authors: Authors: Dhe-Paganon S, Duda K, Iwamoto M, Chi YI, Shoelson SE.
J Biol Chem
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Structure of the globular tail of nuclear lamin.
Authors: Authors: Dhe-Paganon S, Werner ED, Chi YI, Shoelson SE.
J Biol Chem
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Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes.
Authors: Authors: Hundal RS, Petersen KF, Mayerson AB, Randhawa PS, Inzucchi S, Shoelson SE, Shulman GI.
J Clin Invest
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Genetic variability in insulin action inhibitor Ikkbeta (IKBKB) does not play a major role in the development of type 2 diabetes.
Authors: Authors: Menzaghi C, Plengvidhya N, Ma X, Warram JH, Shoelson SE, Doria A.
J Clin Endocrinol Metab
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Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action.
Authors: Authors: Aguirre V, Werner ED, Giraud J, Lee YH, Shoelson SE, White MF.
J Biol Chem
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Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta.
Authors: Authors: Yuan M, Konstantopoulos N, Lee J, Hansen L, Li ZW, Karin M, Shoelson SE.
Science
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