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Steven E. Shoelson, M.D., Ph.D.

Professor of Medicine
617-732-2528
Publications View
SH2 domains exhibit high-affinity binding to tyrosine-phosphorylated peptides yet also exhibit rapid dissociation and exchange.
Authors: Authors: Felder S, Zhou M, Hu P, Ureña J, Ullrich A, Chaudhuri M, White M, Shoelson SE, Schlessinger J.
Mol Cell Biol
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Insulin receptor autophosphorylation occurs asymmetrically.
Authors: Authors: Lee J, O'Hare T, Pilch PF, Shoelson SE.
J Biol Chem
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BpaB25 insulins. Photoactivatable analogues that quantitatively cross-link, radiolabel, and activate the insulin receptor.
Authors: Authors: Shoelson SE, Lee J, Lynch CS, Backer JM, Pilch PF.
J Biol Chem
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Specific phosphopeptide binding regulates a conformational change in the PI 3-kinase SH2 domain associated with enzyme activation.
Authors: Authors: Shoelson SE, Sivaraja M, Williams KP, Hu P, Schlessinger J, Weiss MA.
EMBO J
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Paradoxical structure and function in a mutant human insulin associated with diabetes mellitus.
Authors: Authors: Hua QX, Shoelson SE, Inouye K, Weiss MA.
Proc Natl Acad Sci U S A
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The insulin receptor and its substrate: molecular determinants of early events in insulin action.
Authors: Authors: Kahn CR, White MF, Shoelson SE, Backer JM, Araki E, Cheatham B, Csermely P, Folli F, Goldstein BJ, Huertas P, et al.
Recent Prog Horm Res
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Nonlocal structural perturbations in a mutant human insulin: sequential resonance assignment and 13C-isotope-aided 2D-NMR studies of [PheB24-->Gly]insulin with implications for receptor recognition.
Authors: Authors: Hua QX, Shoelson SE, Weiss MA.
Biochemistry
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Preferential cleavage of des-31,32-proinsulin over intact proinsulin by the insulin secretory granule type II endopeptidase. Implication of a favored route for prohormone processing.
Authors: Authors: Rhodes CJ, Lincoln B, Shoelson SE.
J Biol Chem
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IRS-1 activates phosphatidylinositol 3'-kinase by associating with src homology 2 domains of p85.
Authors: Authors: Myers MG, Backer JM, Sun XJ, Shoelson S, Hu P, Schlessinger J, Yoakim M, Schaffhausen B, White MF.
Proc Natl Acad Sci U S A
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Insulin differentially regulates protein phosphotyrosine phosphatase activity in rat hepatoma cells.
Authors: Authors: Meyerovitch J, Backer JM, Csermely P, Shoelson SE, Kahn CR.
Biochemistry
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