Publications View
Substitution of the erbB-2 oncoprotein transmembrane domain activates the insulin receptor and modulates the action of insulin and insulin-receptor substrate 1.
Authors: Authors: Cheatham B, Shoelson SE, Yamada K, Goncalves E, Kahn CR.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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Optimizing transmembrane domain helicity accelerates insulin receptor internalization and lateral mobility.
Authors: Authors: Goncalves E, Yamada K, Thatte HS, Backer JM, Golan DE, Kahn CR, Shoelson SE.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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Kinetics of p56lck and p60src Src homology 2 domain binding to tyrosine-phosphorylated peptides determined by a competition assay or surface plasmon resonance.
Authors: Authors: Payne G, Shoelson SE, Gish GD, Pawson T, Walsh CT.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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Phosphoinositide 3-kinase is activated by phosphopeptides that bind to the SH2 domains of the 85-kDa subunit.
Authors: Authors: Carpenter CL, Auger KR, Chanudhuri M, Yoakim M, Schaffhausen B, Shoelson S, Cantley LC.
J Biol Chem
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J Biol Chem
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Association of IRS-1 with the insulin receptor and the phosphatidylinositol 3'-kinase. Formation of binary and ternary signaling complexes in intact cells.
Authors: Authors: Backer JM, Myers MG, Sun XJ, Chin DJ, Shoelson SE, Miralpeix M, White MF.
J Biol Chem
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J Biol Chem
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Phosphatidylinositol 3-kinase p85 SH2 domain specificity defined by direct phosphopeptide/SH2 domain binding.
Authors: Authors: Piccione E, Case RD, Domchek SM, Hu P, Chaudhuri M, Backer JM, Schlessinger J, Shoelson SE.
Biochemistry
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Biochemistry
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A photoaffinity scan maps regions of the p85 SH2 domain involved in phosphoprotein binding.
Binding of a high affinity phosphotyrosyl peptide to the Src SH2 domain: crystal structures of the complexed and peptide-free forms.
Authors: Authors: Waksman G, Shoelson SE, Pant N, Cowburn D, Kuriyan J.
Cell
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Cell
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SH2 domains recognize specific phosphopeptide sequences.
Authors: Authors: Songyang Z, Shoelson SE, Chaudhuri M, Gish G, Pawson T, Haser WG, King F, Roberts T, Ratnofsky S, Lechleider RJ, et al.
Cell
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Cell
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Recognition of a high-affinity phosphotyrosyl peptide by the Src homology-2 domain of p56lck.