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Steven E. Shoelson, M.D., Ph.D.

Professor of Medicine
617-732-2528
Publications View
Syp (SH-PTP2) is a positive mediator of growth factor-stimulated mitogenic signal transduction.
Authors: Authors: Xiao S, Rose DW, Sasaoka T, Maegawa H, Burke TR, Roller PP, Shoelson SE, Olefsky JM.
J Biol Chem
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Cyclic peptide inhibitors of phosphatidylinositol 3-kinase p85 SH2 domain binding.
Authors: Authors: Burke TR, Nomizu M, Otaka A, Smyth MS, Roller PP, Case RD, Wolf G, Shoelson SE.
Biochem Biophys Res Commun
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Nonhydrolyzable phosphotyrosyl mimetics for the preparation of phosphatase-resistant SH2 domain inhibitors.
Authors: Authors: Burke TR, Smyth MS, Otaka A, Nomizu M, Roller PP, Wolf G, Case R, Shoelson SE.
Biochemistry
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Backbone dynamics of a free and phosphopeptide-complexed Src homology 2 domain studied by 15N NMR relaxation.
Authors: Authors: Farrow NA, Muhandiram R, Singer AU, Pascal SM, Kay CM, Gish G, Shoelson SE, Pawson T, Forman-Kay JD, Kay LE.
Biochemistry
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Crystal structures of peptide complexes of the amino-terminal SH2 domain of the Syp tyrosine phosphatase.
Authors: Authors: Lee CH, Kominos D, Jacques S, Margolis B, Schlessinger J, Shoelson SE, Kuriyan J.
Structure
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Rapid T-cell receptor-mediated tyrosine phosphorylation of p120, an Fyn/Lck Src homology 3 domain-binding protein.
Authors: Authors: Reedquist KA, Fukazawa T, Druker B, Panchamoorthy G, Shoelson SE, Band H.
Proc Natl Acad Sci U S A
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Activation of the SH2-containing protein tyrosine phosphatase, SH-PTP2, by phosphotyrosine-containing peptides derived from insulin receptor substrate-1.
Authors: Authors: Sugimoto S, Wandless TJ, Shoelson SE, Neel BG, Walsh CT.
J Biol Chem
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Nuclear magnetic resonance structure of an SH2 domain of phospholipase C-gamma 1 complexed with a high affinity binding peptide.
Authors: Authors: Pascal SM, Singer AU, Gish G, Yamazaki T, Shoelson SE, Pawson T, Kay LE, Forman-Kay JD.
Cell
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Structure of the regulatory domains of the Src-family tyrosine kinase Lck.
Authors: Authors: Eck MJ, Atwell SK, Shoelson SE, Harrison SC.
Nature
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SH-PTP2/Syp SH2 domain binding specificity is defined by direct interactions with platelet-derived growth factor beta-receptor, epidermal growth factor receptor, and insulin receptor substrate-1-derived phosphopeptides.
Authors: Authors: Case RD, Piccione E, Wolf G, Benett AM, Lechleider RJ, Neel BG, Shoelson SE.
J Biol Chem
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