Qinheng Zheng, Ph.D.
Assistant Professor of Biological Chemistry and Molecular Pharmacology
Qinheng received his BS from Peking University in 2014 and his PhD in chemistry from The Scripps Research Institute in 2020, where he studied the synthesis, catalysis, and functions of hexavalent sulfur fluoride compounds with Professor K. Barry Sharpless. After four years of post-doctoral training in chemical biology with Professor Kevan Shokat at UCSF, Zheng founded his lab at Harvard Medical School. The Zheng Lab uses organic chemistry, chemical biology and cancer biology to develop covalent compounds that allow chemical rescue of somatic mutations in cancer currently considered “undruggable”.
Publications View
Strain-release alkylation of Asp12 enables mutant selective targeting of K-Ras-G12D.
Authors: Authors: Zheng Q, Zhang Z, Guiley KZ, Shokat KM.
Nat Chem Biol
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Nat Chem Biol
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Nanomolar Protein Thermal Profiling with Modified Cyanine Dyes.
Authors: Authors: Malakoutikhah M, Mahran R, Gooran N, Masoumi A, Lundell K, Liljeblad A, Guiley K, Dai S, Zheng Q, Zhu L, Shokat KM, Kopra K, Härmä H.
Anal Chem
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Anal Chem
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Sulfur fluoride exchange.
Authors: Authors: Homer JA, Xu L, Kayambu N, Zheng Q, Choi EJ, Kim BM, Sharpless KB, Zuilhof H, Dong J, Moses JE.
Nat Rev Methods Primers
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Nat Rev Methods Primers
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KRAS is vulnerable to reversible switch-II pocket engagement in cells.
Authors: Authors: Vasta JD, Peacock DM, Zheng Q, Walker JA, Zhang Z, Zimprich CA, Thomas MR, Beck MT, Binkowski BF, Corona CR, Robers MB, Shokat KM.
Nat Chem Biol
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Nat Chem Biol
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Drugging the Next Undruggable KRAS Allele-Gly12Asp.
Chemical Inhibition of ENL/AF9 YEATS Domains in Acute Leukemia.
Authors: Authors: Garnar-Wortzel L, Bishop TR, Kitamura S, Milosevich N, Asiaban JN, Zhang X, Zheng Q, Chen E, Ramos AR, Ackerman CJ, Hampton EN, Chatterjee AK, Young TS, Hull MV, Sharpless KB, Cravatt BF, Wolan DW, Erb MA.
ACS Cent Sci
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ACS Cent Sci
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Sulfur [18F]Fluoride Exchange Click Chemistry Enabled Ultrafast Late-Stage Radiosynthesis.
Authors: Authors: Zheng Q, Xu H, Wang H, Du WH, Wang N, Xiong H, Gu Y, Noodleman L, Sharpless KB, Yang G, Wu P.
J Am Chem Soc
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J Am Chem Soc
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Sulfur(VI) Fluoride Exchange (SuFEx)-Enabled High-Throughput Medicinal Chemistry.
Authors: Authors: Kitamura S, Zheng Q, Woehl JL, Solania A, Chen E, Dillon N, Hull MV, Kotaniguchi M, Cappiello JR, Kitamura S, Nizet V, Sharpless KB, Wolan DW.
J Am Chem Soc
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J Am Chem Soc
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SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase.
Authors: Authors: Zheng Q, Woehl JL, Kitamura S, Santos-Martins D, Smedley CJ, Li G, Forli S, Moses JE, Wolan DW, Sharpless KB.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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Bifluoride Ion Mediated SuFEx Trifluoromethylation of Sulfonyl Fluorides and Iminosulfur Oxydifluorides.
Authors: Authors: Smedley CJ, Zheng Q, Gao B, Li S, Molino A, Duivenvoorden HM, Parker BS, Wilson DJD, Sharpless KB, Moses JE.
Angew Chem Int Ed Engl
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Angew Chem Int Ed Engl
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