Qinheng Zheng, Ph.D.
Assistant Professor of Biological Chemistry and Molecular Pharmacology
Qinheng received his BS from Peking University in 2014 and his PhD in chemistry from The Scripps Research Institute in 2020, where he studied the synthesis, catalysis, and functions of hexavalent sulfur fluoride compounds with Professor K. Barry Sharpless. After four years of post-doctoral training in chemical biology with Professor Kevan Shokat at UCSF, Zheng founded his lab at Harvard Medical School. The Zheng Lab uses organic chemistry, chemical biology and cancer biology to develop covalent compounds that allow chemical rescue of somatic mutations in cancer currently considered “undruggable”.
Publications View
Quantitative and Orthogonal Formation and Reactivity of SuFEx Platforms.
Authors: Authors: Gahtory D, Sen R, Pujari S, Li S, Zheng Q, Moses JE, Sharpless KB, Zuilhof H.
Chemistry
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Chemistry
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Bifluoride-catalysed sulfur(VI) fluoride exchange reaction for the synthesis of polysulfates and polysulfonates.
Authors: Authors: Gao B, Zhang L, Zheng Q, Zhou F, Klivansky LM, Lu J, Liu Y, Dong J, Wu P, Sharpless KB.
Nat Chem
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Nat Chem
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SuFEx-Based Polysulfonate Formation from Ethenesulfonyl Fluoride-Amine Adducts.
Authors: Authors: Wang H, Zhou F, Ren G, Zheng Q, Chen H, Gao B, Klivansky L, Liu Y, Wu B, Xu Q, Lu J, Sharpless KB, Wu P.
Angew Chem Int Ed Engl
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Angew Chem Int Ed Engl
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Addition to "Aryl Fluorosulfate Trapped Staudinger Reduction".
Palladium-Catalyzed Fluorosulfonylvinylation of Organic Iodides.
Authors: Authors: Zha GF, Zheng Q, Leng J, Wu P, Qin HL, Sharpless KB.
Angew Chem Int Ed Engl
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Angew Chem Int Ed Engl
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Aryl Fluorosulfate Trapped Staudinger Reduction.
Ethenesulfonyl Fluoride (ESF): An On-Water Procedure for the Kilogram-Scale Preparation.
A Heck-Matsuda Process for the Synthesis of ß-Arylethenesulfonyl Fluorides: Selectively Addressable Bis-electrophiles for SuFEx Click Chemistry.
Authors: Authors: Qin HL, Zheng Q, Bare GA, Wu P, Sharpless KB.
Angew Chem Int Ed Engl
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Angew Chem Int Ed Engl
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Mild-condition synthesis of allenes from alkynes and aldehydes mediated by tetrahydroisoquinoline (THIQ).
Authors: Authors: Jiang GJ, Zheng QH, Dou M, Zhuo LG, Meng W, Yu ZX.
J Org Chem
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J Org Chem
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CuI-catalyzed C1-alkynylation of tetrahydroisoquinolines (THIQs) by A3 reaction with tunable iminium ions.