Piotr Sliz

Piotr Sliz, Ph.D.

Associate Professor of Pediatrics
Associate Professor of Biological Chemistry and Molecular Pharmacology

Our primary research interest is to understand the molecular details of specialized, noncanonical mechanisms that regulate gene expression.

Research:

Our primary research interest is to understand the molecular details of specialized, noncanonical mechanisms that regulate gene expression. Various proteins have evolved to act as specific modulators of genes in order to fine-tune their activity as well as to quickly respond to environmental cues. We focus on investigating the regulators that are directly involved in major human diseases such as cancer and diabetes. By employing biochemical and structural approaches, we not only aim to understand the molecular mechanism, but also to use the details provided by high-resolution structures for identifying potential therapeutic avenues. For appropriate candidate macromolecules we utilize computational techniques such as molecular dynamics and in silico docking to design small molecule inhibitors and to understand their interactions.

Address: 

C Building, Room 215

240 Longwood Avenue

Boston, MA 02115

Publications View
Extension of research data repository system to support direct compute access to biomedical datasets: enhancing Dataverse to support large datasets.
Authors: Authors: McKinney B, Meyer PA, Crosas M, Sliz P.
Ann N Y Acad Sci
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LIN28 Regulates Stem Cell Metabolism and Conversion to Primed Pluripotency.
Authors: Authors: Zhang J, Ratanasirintrawoot S, Chandrasekaran S, Wu Z, Ficarro SB, Yu C, Ross CA, Cacchiarelli D, Xia Q, Seligson M, Shinoda G, Xie W, Cahan P, Wang L, Ng SC, Tintara S, Trapnell C, Onder T, Loh YH, Mikkelsen T, Sliz P, Teitell MA, Asara JM, Marto JA, Li H, Collins JJ, Daley GQ.
Cell Stem Cell
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Data publication with the structural biology data grid supports live analysis.
Authors: Authors: Meyer PA, Socias S, Key J, Ransey E, Tjon EC, Buschiazzo A, Lei M, Botka C, Withrow J, Neau D, Rajashankar K, Anderson KS, Baxter RH, Blacklow SC, Boggon TJ, Bonvin AM, Borek D, Brett TJ, Caflisch A, Chang CI, Chazin WJ, Corbett KD, Cosgrove MS, Crosson S, Dhe-Paganon S, Di Cera E, Drennan CL, Eck MJ, Eichman BF, Fan QR, Ferré-D'Amaré AR, Fromme JC, Garcia KC, Gaudet R, Gong P, Harrison SC, Heldwein EE, Jia Z, Keenan RJ, Kruse AC, Kvansakul M, McLellan JS, Modis Y, Nam Y, Otwinowski Z, Pai EF, Pereira PJ, Petosa C, Raman CS, Rapoport TA, Roll-Mecak A, Rosen MK, Rudenko G, Schlessinger J, Schwartz TU, Shamoo Y, Sondermann H, Tao YJ, Tolia NH, Tsodikov OV, Westover KD, Wu H, Foster I, Fraser JS, Maia FR, Gonen T, Kirchhausen T, Diederichs K, Crosas M, Sliz P.
Nat Commun
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Pinpointing RNA-Protein Cross-Links with Site-Specific Stable Isotope-Labeled Oligonucleotides.
Authors: Authors: Lelyveld VS, Björkbom A, Ransey EM, Sliz P, Szostak JW.
J Am Chem Soc
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A Biogenesis Step Upstream of Microprocessor Controls miR-17~92 Expression.
Authors: Authors: Du P, Wang L, Sliz P, Gregory RI.
Cell
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AppCiter: A Web Application for Increasing Rates and Accuracy of Scientific Software Citation.
Authors: Authors: Socias SM, Morin A, Timony MA, Sliz P.
Structure
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Science and technology consortia in U.S. biomedical research: a paradigm shift in response to unsustainable academic growth.
Authors: Authors: Balch C, Arias-Pulido H, Banerjee S, Lancaster AK, Clark KB, Perilstein M, Hawkins B, Rhodes J, Sliz P, Wilkins J, Chittenden TW.
Bioessays
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Selective microRNA uridylation by Zcchc6 (TUT7) and Zcchc11 (TUT4).
Authors: Authors: Thornton JE, Du P, Jing L, Sjekloca L, Lin S, Grossi E, Sliz P, Zon LI, Gregory RI.
Nucleic Acids Res
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Chemical interrogation of the malaria kinome.
Authors: Authors: Derbyshire ER, Zuzarte-Luís V, Magalhães AD, Kato N, Sanschagrin PC, Wang J, Zhou W, Miduturu CV, Mazitschek R, Sliz P, Mota MM, Gray NS, Clardy J.
Chembiochem
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Structural biology computing: Lessons for the biomedical research sciences.
Authors: Authors: Morin A, Sliz P.
Biopolymers
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