Piotr Sliz
Piotr Sliz, Ph.D.
Associate Professor of Pediatrics

Our primary research interest is to understand the molecular details of specialized, noncanonical mechanisms that regulate gene expression.

Research:

Our primary research interest is to understand the molecular details of specialized, noncanonical mechanisms that regulate gene expression. Various proteins have evolved to act as specific modulators of genes in order to fine-tune their activity as well as to quickly respond to environmental cues. We focus on investigating the regulators that are directly involved in major human diseases such as cancer and diabetes. By employing biochemical and structural approaches, we not only aim to understand the molecular mechanism, but also to use the details provided by high-resolution structures for identifying potential therapeutic avenues. For appropriate candidate macromolecules we utilize computational techniques such as molecular dynamics and in silico docking to design small molecule inhibitors and to understand their interactions.

Address: 

C Building, Room 215

240 Longwood Avenue

Boston, MA 02115

Publications View
In silico Screening and Evaluation of Plasmodium falciparum Protein Kinase 5 (PK5) Inhibitors.
Authors: Authors: Eubanks AL, Perkins MM, Sylvester K, Ganley JG, Posfai D, Sanschargrin PC, Hong J, Sliz P, Derbyshire ER.
ChemMedChem
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mRNA circularization by METTL3-eIF3h enhances translation and promotes oncogenesis.
Authors: Authors: Choe J, Lin S, Zhang W, Liu Q, Wang L, Ramirez-Moya J, Du P, Kim W, Tang S, Sliz P, Santisteban P, George RE, Richards WG, Wong KK, Locker N, Slack FJ, Gregory RI.
Nature
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Small-Molecule Inhibitors Disrupt let-7 Oligouridylation and Release the Selective Blockade of let-7 Processing by LIN28.
Authors: Authors: Wang L, Rowe RG, Jaimes A, Yu C, Nam Y, Pearson DS, Zhang J, Xie X, Marion W, Heffron GJ, Daley GQ, Sliz P.
Cell Rep
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MightyScreen: An Open-Source Visualization Application for Screening Data Analysis.
Authors: Authors: Wang L, Yang Q, Jaimes A, Wang T, Strobelt H, Chen J, Sliz P.
SLAS Discov
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Development of the Precision Link Biobank at Boston Children's Hospital: Challenges and Opportunities.
Authors: Authors: Bourgeois FT, Avillach P, Kong SW, Heinz MM, Tran TA, Chakrabarty R, Bickel J, Sliz P, Borglund EM, Kornetsky S, Mandl KD.
J Pers Med
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Comparative analysis of LIN28-RNA binding sites identified at single nucleotide resolution.
Authors: Authors: Ransey E, Björkbom A, Lelyveld VS, Biecek P, Pantano L, Szostak JW, Sliz P.
RNA Biol
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LIN28 Zinc Knuckle Domain Is Required and Sufficient to Induce let-7 Oligouridylation.
Authors: Authors: Wang L, Nam Y, Lee AK, Yu C, Roth K, Chen C, Ransey EM, Sliz P.
Cell Rep
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Cryo-EM structure of the replisome reveals multiple interactions coordinating DNA synthesis.
Authors: Authors: Kulczyk AW, Moeller A, Meyer P, Sliz P, Richardson CC.
Proc Natl Acad Sci U S A
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STK40 Is a Pseudokinase that Binds the E3 Ubiquitin Ligase COP1.
Authors: Authors: Durzynska I, Xu X, Adelmant G, Ficarro SB, Marto JA, Sliz P, Uljon S, Blacklow SC.
Structure
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Pulmonary Vasculopathy Associated with FIGF Gene Mutation.
Authors: Authors: Bailey E, Cui Y, Casey A, Stoler JM, Ai X, Ma D, Handin R, Sliz P, Vargas SO, El-Chemaly SY.
Am J Pathol
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