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Morris Francis White Jr., Ph.D.

Professor of Pediatrics
617-732-2578
Publications View
Nutrient-dependent and insulin-stimulated phosphorylation of insulin receptor substrate-1 on serine 302 correlates with increased insulin signaling.
Authors: Authors: Giraud J, Leshan R, Lee YH, White MF.
J Biol Chem
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Islet-sparing effects of protein tyrosine phosphatase-1b deficiency delays onset of diabetes in IRS2 knockout mice.
Authors: Authors: Kushner JA, Haj FG, Klaman LD, Dow MA, Kahn BB, Neel BG, White MF.
Diabetes
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Insulin signaling in health and disease.
Authors: Authors: White MF.
Science
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Upregulation of insulin receptor substrate-2 in pancreatic beta cells prevents diabetes.
Authors: Authors: Hennige AM, Burks DJ, Ozcan U, Kulkarni RN, Ye J, Park S, Schubert M, Fisher TL, Dow MA, Leshan R, Zakaria M, Mossa-Basha M, White MF.
J Clin Invest
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Molecular mechanisms of insulin resistance in IRS-2-deficient hepatocytes.
Authors: Authors: Valverde AM, Burks DJ, Fabregat I, Fisher TL, Carretero J, White MF, Benito M.
Diabetes
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Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation.
Authors: Authors: Schubert M, Brazil DP, Burks DJ, Kushner JA, Ye J, Flint CL, Farhang-Fallah J, Dikkes P, Warot XM, Rio C, Corfas G, White MF.
J Neurosci
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cAMP promotes pancreatic beta-cell survival via CREB-mediated induction of IRS2.
Authors: Authors: Jhala US, Canettieri G, Screaton RA, Kulkarni RN, Krajewski S, Reed J, Walker J, Lin X, White M, Montminy M.
Genes Dev
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Essential role of protein kinase C zeta in the impairment of insulin-induced glucose transport in IRS-2-deficient brown adipocytes.
Authors: Authors: Arribas M, Valverde AM, Burks D, Klein J, Farese RV, White MF, Benito M.
FEBS Lett
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c-Jun N-terminal kinase (JNK) mediates feedback inhibition of the insulin signaling cascade.
Authors: Authors: Lee YH, Giraud J, Davis RJ, White MF.
J Biol Chem
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Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle.
Authors: Authors: Yu C, Chen Y, Cline GW, Zhang D, Zong H, Wang Y, Bergeron R, Kim JK, Cushman SW, Cooney GJ, Atcheson B, White MF, Kraegen EW, Shulman GI.
J Biol Chem
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