Dominic M. Walsh

Dominic M. Walsh, Ph.D.

Lecturer on Neurology

617-525-5059

Publications

Publications View

Human anti-Aß IgGs target conformational epitopes on synthetic dimer assemblies and the AD brain-derived peptide.

Authors: Authors: Welzel AT, Williams AD, McWilliams-Koeppen HP, Acero L, Weber A, Blinder V, Mably A, Bunk S, Hermann C, Farrell MA, Ehrlich HJ, Schwarz HP, Walsh DM, Solomon A, O'Nuallain B.
PLoS One 2012-01-01
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Alzheimer's disease and the amyloid ß-protein.

Authors: Authors: Walsh DM, Teplow DB.
Prog Mol Biol Transl Sci 2012-01-01
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Aß oligomers inhibit synapse remodelling necessary for memory consolidation.

Authors: Authors: Freir DB, Fedriani R, Scully D, Smith IM, Selkoe DJ, Walsh DM, Regan CM.
Neurobiol Aging 2011-12-01
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Small-molecule conversion of toxic oligomers to nontoxic ß-sheet-rich amyloid fibrils.

Authors: Authors: Bieschke J, Herbst M, Wiglenda T, Friedrich RP, Boeddrich A, Schiele F, Kleckers D, Lopez del Amo JM, Grüning BA, Wang Q, Schmidt MR, Lurz R, Anwyl R, Schnoegl S, Fändrich M, Frank RF, Reif B, Günther S, Walsh DM, Wanker EE.
Nat Chem Biol 2011-11-20
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Cognitive effects of cell-derived and synthetically derived Aß oligomers.

Authors: Authors: Reed MN, Hofmeister JJ, Jungbauer L, Welzel AT, Yu C, Sherman MA, Lesné S, LaDu MJ, Walsh DM, Ashe KH, Cleary JP.
Neurobiol Aging 2011-10-01
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A monoclonal antibody against synthetic Aß dimer assemblies neutralizes brain-derived synaptic plasticity-disrupting Aß.

Authors: Authors: O'Nuallain B, Klyubin I, Mc Donald JM, Foster JS, Welzel A, Barry A, Dykoski RK, Cleary JP, Gebbink MF, Rowan MJ, Walsh DM.
J Neurochem 2011-10-01
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Interaction between prion protein and toxic amyloid ß assemblies can be therapeutically targeted at multiple sites.

Authors: Authors: Freir DB, Nicoll AJ, Klyubin I, Panico S, Mc Donald JM, Risse E, Asante EA, Farrow MA, Sessions RB, Saibil HR, Clarke AR, Rowan MJ, Walsh DM, Collinge J.
Nat Commun 2011-06-07
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Extracellular phosphorylation of the amyloid ß-peptide promotes formation of toxic aggregates during the pathogenesis of Alzheimer's disease.

Authors: Authors: Kumar S, Rezaei-Ghaleh N, Terwel D, Thal DR, Richard M, Hoch M, Mc Donald JM, Wüllner U, Glebov K, Heneka MT, Walsh DM, Zweckstetter M, Walter J.
EMBO J 2011-06-01
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Alzheimer's disease brain-derived amyloid-ß-mediated inhibition of LTP in vivo is prevented by immunotargeting cellular prion protein.

Authors: Authors: Barry AE, Klyubin I, Mc Donald JM, Mably AJ, Farrell MA, Scott M, Walsh DM, Rowan MJ.
J Neurosci 2011-05-18
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Soluble amyloid beta-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration.

Authors: Authors: Jin M, Shepardson N, Yang T, Chen G, Walsh D, Selkoe DJ.
Proc Natl Acad Sci U S A 2011-04-05
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