HMS placeholder

Dominic M. Walsh, Ph.D.

Lecturer on Neurology
617-525-5059
Publications View
The familial Alzheimer's disease APPV717I mutation alters APP processing and Tau expression in iPSC-derived neurons.
Authors: Authors: Muratore CR, Rice HC, Srikanth P, Callahan DG, Shin T, Benjamin LN, Walsh DM, Selkoe DJ, Young-Pearse TL.
Hum Mol Genet
View full abstract on Pubmed
Secreted amyloid ß-proteins in a cell culture model include N-terminally extended peptides that impair synaptic plasticity.
Authors: Authors: Welzel AT, Maggio JE, Shankar GM, Walker DE, Ostaszewski BL, Li S, Klyubin I, Rowan MJ, Seubert P, Walsh DM, Selkoe DJ.
Biochemistry
View full abstract on Pubmed
APP homodimers transduce an amyloid-ß-mediated increase in release probability at excitatory synapses.
Authors: Authors: Fogel H, Frere S, Segev O, Bharill S, Shapira I, Gazit N, O'Malley T, Slomowitz E, Berdichevsky Y, Walsh DM, Isacoff EY, Hirsch JA, Slutsky I.
Cell Rep
View full abstract on Pubmed
Simultaneous measurement of a range of particle sizes during Aß1-42 fibrillogenesis quantified using fluorescence correlation spectroscopy.
Authors: Authors: Mittag JJ, Milani S, Walsh DM, Rädler JO, McManus JJ.
Biochem Biophys Res Commun
View full abstract on Pubmed
Peripheral administration of a humanized anti-PrP antibody blocks Alzheimer's disease Aß synaptotoxicity.
Authors: Authors: Klyubin I, Nicoll AJ, Khalili-Shirazi A, Farmer M, Canning S, Mably A, Linehan J, Brown A, Wakeling M, Brandner S, Walsh DM, Rowan MJ, Collinge J.
J Neurosci
View full abstract on Pubmed
Transthyretin aggregate-specific antibodies recognize cryptic epitopes on patient-derived amyloid fibrils.
Authors: Authors: Phay M, Blinder V, Macy S, Greene MJ, Wooliver DC, Liu W, Planas A, Walsh DM, Connors LH, Primmer SR, Planque SA, Paul S, O'Nuallain B.
Rejuvenation Res
View full abstract on Pubmed
mGlu5 receptors and cellular prion protein mediate amyloid-ß-facilitated synaptic long-term depression in vivo.
Authors: Authors: Hu NW, Nicoll AJ, Zhang D, Mably AJ, O'Malley T, Purro SA, Terry C, Collinge J, Walsh DM, Rowan MJ.
Nat Commun
View full abstract on Pubmed
Neurotransmitter receptor and time dependence of the synaptic plasticity disrupting actions of Alzheimer's disease Aß in vivo.
Authors: Authors: Klyubin I, Ondrejcak T, Hayes J, Cullen WK, Mably AJ, Walsh DM, Rowan MJ.
Philos Trans R Soc Lond B Biol Sci
View full abstract on Pubmed
Simvastatin treatment preserves synaptic plasticity in AßPPswe/PS1dE9 mice.
Authors: Authors: Métais C, Brennan K, Mably AJ, Scott M, Walsh DM, Herron CE.
J Alzheimers Dis
View full abstract on Pubmed
Exosomes neutralize synaptic-plasticity-disrupting activity of Aß assemblies in vivo.
Authors: Authors: An K, Klyubin I, Kim Y, Jung JH, Mably AJ, O'Dowd ST, Lynch T, Kanmert D, Lemere CA, Finan GM, Park JW, Kim TW, Walsh DM, Rowan MJ, Kim JH.
Mol Brain
View full abstract on Pubmed