Publications View
Orally available compound prevents deficits in memory caused by the Alzheimer amyloid-beta oligomers.
Authors: Authors: Townsend M, Cleary JP, Mehta T, Hofmeister J, Lesne S, O'Hare E, Walsh DM, Selkoe DJ.
Ann Neurol
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Ann Neurol
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Common threads in neurodegenerative disorders of aging.
Authors: Authors: Beal MF, Bossy-Wetzel E, Finkbeiner S, Fiskum G, Giasson B, Johnson C, Khachaturian ZS, Lee VM, Nicholls D, Reddy H, Reynolds I, Teplow DB, Thal LJ, Trojanowski JQ, Walsh DM, Wetzel R, Wexler NS, Young AB, Bain L.
Alzheimers Dement
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Alzheimers Dement
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Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host.
Authors: Authors: Meyer-Luehmann M, Coomaraswamy J, Bolmont T, Kaeser S, Schaefer C, Kilger E, Neuenschwander A, Abramowski D, Frey P, Jaton AL, Vigouret JM, Paganetti P, Walsh DM, Mathews PM, Ghiso J, Staufenbiel M, Walker LC, Jucker M.
Science
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Science
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Effects of secreted oligomers of amyloid beta-protein on hippocampal synaptic plasticity: a potent role for trimers.
Authors: Authors: Townsend M, Shankar GM, Mehta T, Walsh DM, Selkoe DJ.
J Physiol
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J Physiol
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The role of cell-derived oligomers of Abeta in Alzheimer's disease and avenues for therapeutic intervention.
Authors: Authors: Walsh DM, Klyubin I, Shankar GM, Townsend M, Fadeeva JV, Betts V, Podlisny MB, Cleary JP, Ashe KH, Rowan MJ, Selkoe DJ.
Biochem Soc Trans
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Biochem Soc Trans
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Amyloid beta protein immunotherapy neutralizes Abeta oligomers that disrupt synaptic plasticity in vivo.
Authors: Authors: Klyubin I, Walsh DM, Lemere CA, Cullen WK, Shankar GM, Betts V, Spooner ET, Jiang L, Anwyl R, Selkoe DJ, Rowan MJ.
Nat Med
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Nat Med
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Certain inhibitors of synthetic amyloid beta-peptide (Abeta) fibrillogenesis block oligomerization of natural Abeta and thereby rescue long-term potentiation.
Authors: Authors: Walsh DM, Townsend M, Podlisny MB, Shankar GM, Fadeeva JV, El Agnaf O, Hartley DM, Selkoe DJ.
J Neurosci
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J Neurosci
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Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function.
Authors: Authors: Cleary JP, Walsh DM, Hofmeister JJ, Shankar GM, Kuskowski MA, Selkoe DJ, Ashe KH.
Nat Neurosci
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Nat Neurosci
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Species-specific immune response to immunization with human versus rodent A beta peptide.
Authors: Authors: Seabrook TJ, Bloom JK, Iglesias M, Spooner ET, Walsh DM, Lemere CA.
Neurobiol Aging
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Neurobiol Aging
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Deciphering the molecular basis of memory failure in Alzheimer's disease.