Anthony George Letai

Anthony George Letai, M.D., Ph.D.

Professor of Medicine

617-632-2348

Publications

Publications View

BCL-2 inhibition: stemming the tide of myeloid malignancies.

Authors: Authors: Hogdal LJ, Letai A.
Cell Stem Cell 2013-03-07
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ABT-199: taking dead aim at BCL-2.

Authors: Authors: Davids MS, Letai A.
Cancer Cell 2013-02-11
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Priming BCL-2 to kill: the combination therapy of tamoxifen and ABT-199 in ER+ breast cancer.

Authors: Authors: Deng J, Letai A.
Breast Cancer Res 2013-01-01
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Decreased mitochondrial apoptotic priming underlies stroma-mediated treatment resistance in chronic lymphocytic leukemia.

Authors: Authors: Davids MS, Deng J, Wiestner A, Lannutti BJ, Wang L, Wu CJ, Wilson WH, Brown JR, Letai A.
Blood 2012-10-25
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Relative mitochondrial priming of myeloblasts and normal HSCs determines chemotherapeutic success in AML.

Authors: Authors: Vo TT, Ryan J, Carrasco R, Neuberg D, Rossi DJ, Stone RM, Deangelo DJ, Frattini MG, Letai A.
Cell 2012-10-12
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Reactivation of ERK signaling causes resistance to EGFR kinase inhibitors.

Authors: Authors: Ercan D, Xu C, Yanagita M, Monast CS, Pratilas CA, Montero J, Butaney M, Shimamura T, Sholl L, Ivanova EV, Tadi M, Rogers A, Repellin C, Capelletti M, Maertens O, Goetz EM, Letai A, Garraway LA, Lazzara MJ, Rosen N, Gray NS, Wong KK, Jänne PA.
Cancer Discov 2012-10-01
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Targeting the B-cell lymphoma/leukemia 2 family in cancer.

Authors: Authors: Davids MS, Letai A.
J Clin Oncol 2012-09-01
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BCL2 suppresses PARP1 function and nonapoptotic cell death.

Authors: Authors: Dutta C, Day T, Kopp N, van Bodegom D, Davids MS, Ryan J, Bird L, Kommajosyula N, Weigert O, Yoda A, Fung H, Brown JR, Shapiro GI, Letai A, Weinstock DM.
Cancer Res 2012-08-15
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BH3-only proteins are part of a regulatory network that control the sustained signalling of the unfolded protein response sensor IRE1a.

Authors: Authors: Rodriguez DA, Zamorano S, Lisbona F, Rojas-Rivera D, Urra H, Cubillos-Ruiz JR, Armisen R, Henriquez DR, Cheng EH, Letek M, Vaisar T, Irrazabal T, Gonzalez-Billault C, Letai A, Pimentel-Muiños FX, Kroemer G, Hetz C.
EMBO J 2012-05-16
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P-selectin glycoprotein ligand regulates the interaction of multiple myeloma cells with the bone marrow microenvironment.

Authors: Authors: Azab AK, Quang P, Azab F, Pitsillides C, Thompson B, Chonghaile T, Patton JT, Maiso P, Monrose V, Sacco A, Ngo HT, Flores LM, Lin CP, Magnani JL, Kung AL, Letai A, Carrasco R, Roccaro AM, Ghobrial IM.
Blood 2012-02-09
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