Anthony George Letai

Anthony George Letai, M.D., Ph.D.

Professor of Medicine

617-632-2348

Publications

Publications View

Selective BCL-2 inhibition by ABT-199 causes on-target cell death in acute myeloid leukemia.

Authors: Authors: Pan R, Hogdal LJ, Benito JM, Bucci D, Han L, Borthakur G, Cortes J, DeAngelo DJ, Debose L, Mu H, Döhner H, Gaidzik VI, Galinsky I, Golfman LS, Haferlach T, Harutyunyan KG, Hu J, Leverson JD, Marcucci G, Müschen M, Newman R, Park E, Ruvolo PP, Ruvolo V, Ryan J, Schindela S, Zweidler-McKay P, Stone RM, Kantarjian H, Andreeff M, Konopleva M, Letai AG.
Cancer Discov 2014-03-01
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Bcl-xL controls a switch between cell death modes during mitotic arrest.

Authors: Authors: Bah N, Maillet L, Ryan J, Dubreil S, Gautier F, Letai A, Juin P, Barillé-Nion S.
Cell Death Dis 2014-01-01
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Mitochondria: gatekeepers of response to chemotherapy.

Authors: Authors: Sarosiek KA, Ni Chonghaile T, Letai A.
Trends Cell Biol 2013-12-01
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p53 regulates a non-apoptotic death induced by ROS.

Authors: Authors: Montero J, Dutta C, van Bodegom D, Weinstock D, Letai A.
Cell Death Differ 2013-11-01
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High mitochondrial priming sensitizes hESCs to DNA-damage-induced apoptosis.

Authors: Authors: Liu JC, Guan X, Ryan JA, Rivera AG, Mock C, Agrawal V, Agarwal V, Letai A, Lerou PH, Lahav G.
Cell Stem Cell 2013-10-03
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BID preferentially activates BAK while BIM preferentially activates BAX, affecting chemotherapy response.

Authors: Authors: Sarosiek KA, Chi X, Bachman JA, Sims JJ, Montero J, Patel L, Flanagan A, Andrews DW, Sorger P, Letai A.
Mol Cell 2013-09-26
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Overcoming stroma-mediated treatment resistance in chronic lymphocytic leukemia through BCL-2 inhibition.

Authors: Authors: Davids MS, Letai A, Brown JR.
Leuk Lymphoma 2013-08-01
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BH3 profiling in whole cells by fluorimeter or FACS.

Authors: Authors: Ryan J, Letai A.
Methods 2013-06-01
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BH3 profiling--measuring integrated function of the mitochondrial apoptotic pathway to predict cell fate decisions.

Authors: Authors: Del Gaizo Moore V, Letai A.
Cancer Lett 2013-05-28
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KPT-330 inhibitor of CRM1 (XPO1)-mediated nuclear export has selective anti-leukaemic activity in preclinical models of T-cell acute lymphoblastic leukaemia and acute myeloid leukaemia.

Authors: Authors: Etchin J, Sanda T, Mansour MR, Kentsis A, Montero J, Le BT, Christie AL, McCauley D, Rodig SJ, Kauffman M, Shacham S, Stone R, Letai A, Kung AL, Thomas Look A.
Br J Haematol 2013-04-01
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