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Anthony George Letai, M.D., Ph.D.

Professor of Medicine
617-632-2348
Publications View
RAS signaling promotes resistance to JAK inhibitors by suppressing BAD-mediated apoptosis.
Authors: Authors: Winter PS, Sarosiek KA, Lin KH, Meggendorfer M, Schnittger S, Letai A, Wood KC.
Sci Signal
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Designed BH3 peptides with high affinity and specificity for targeting Mcl-1 in cells.
Authors: Authors: Foight GW, Ryan JA, Gullá SV, Letai A, Keating AE.
ACS Chem Biol
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Increased mitochondrial apoptotic priming of human regulatory T cells after allogeneic hematopoietic stem cell transplantation.
Authors: Authors: Murase K, Kim HT, Bascug OR, Kawano Y, Ryan J, Matsuoka K, Davids MS, Koreth J, Ho VT, Cutler C, Armand P, Alyea EP, Blazar BR, Antin JH, Soiffer RJ, Letai A, Ritz J.
Haematologica
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Cell and molecular determinants of in vivo efficacy of the BH3 mimetic ABT-263 against pediatric acute lymphoblastic leukemia xenografts.
Authors: Authors: Suryani S, Carol H, Chonghaile TN, Frismantas V, Sarmah C, High L, Bornhauser B, Cowley MJ, Szymanska B, Evans K, Boehm I, Tonna E, Jones L, Manesh DM, Kurmasheva RT, Billups C, Kaplan W, Letai A, Bourquin JP, Houghton PJ, Smith MA, Lock RB.
Clin Cancer Res
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Maturation stage of T-cell acute lymphoblastic leukemia determines BCL-2 versus BCL-XL dependence and sensitivity to ABT-199.
Authors: Authors: Chonghaile TN, Roderick JE, Glenfield C, Ryan J, Sallan SE, Silverman LB, Loh ML, Hunger SP, Wood B, DeAngelo DJ, Stone R, Harris M, Gutierrez A, Kelliher MA, Letai A.
Cancer Discov
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Decreased mitochondrial priming determines chemoresistance of colon cancer stem cells.
Authors: Authors: Colak S, Zimberlin CD, Fessler E, Hogdal L, Prasetyanti PR, Grandela CM, Letai A, Medema JP.
Cell Death Differ
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Bcl-xL controls a switch between cell death modes during mitotic arrest.
Authors: Authors: Bah N, Maillet L, Ryan J, Dubreil S, Gautier F, Letai A, Juin P, Barillé-Nion S.
Cell Death Dis
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Failure to induce apoptosis via BCL-2 family proteins underlies lack of efficacy of combined MEK and PI3K inhibitors for KRAS-mutant lung cancers.
Authors: Authors: Hata AN, Yeo A, Faber AC, Lifshits E, Chen Z, Cheng KA, Walton Z, Sarosiek KA, Letai A, Heist RS, Mino-Kenudson M, Wong KK, Engelman JA.
Cancer Res
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APC(Cdc20) suppresses apoptosis through targeting Bim for ubiquitination and destruction.
Authors: Authors: Wan L, Tan M, Yang J, Inuzuka H, Dai X, Wu T, Liu J, Shaik S, Chen G, Deng J, Malumbres M, Letai A, Kirschner MW, Sun Y, Wei W.
Dev Cell
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Modulation of Mcl-1 sensitizes glioblastoma to TRAIL-induced apoptosis.
Authors: Authors: Murphy ÁC, Weyhenmeyer B, Noonan J, Kilbride SM, Schimansky S, Loh KP, Kögel D, Letai AG, Prehn JH, Murphy BM.
Apoptosis
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