Andrew Kruse, Ph.D.
Professor of Biological Chemistry and Molecular Pharmacology
Our research aims to elucidate the molecular basis of membrane protein signaling using techniques including protein engineering, structural biology, and pharmacology.
Research:
Signal transduction across cell membranes plays a central role in human physiology and disease, yet the mechanistic details underlying transmembrane signaling remain poorly understood. Our research aims to elucidate the molecular basis of membrane protein signaling using techniques including protein engineering, structural biology, and pharmacology. In particular, we are focused on the study of proteins important in human health and disease, including G protein-coupled receptors and other proteins that regulate neurotransmission and metabolic homeostasis.
G protein-coupled receptors (GPCRs) are cell-surface receptors that regulate neurotransmission, cardiovascular function, metabolic homeostasis, and many other physiological processes. Due to their central role in human physiology, these receptors are among the most important targets of therapeutic drugs, and are they among the most extensively studied proteins. To better understand GPCR signal transduction at a molecular level, we are using structural biology and biophysical methods to study model GPCRs such as muscarinic acetylcholine receptors. In addition, we are using new approaches in combinatorial biology to facilitate structural studies and to create protein ligands of GPCRs.
We are also interested in signal transduction pathways that remain less extensively studied than GPCRs, particularly receptors involved in the regulation of human metabolic homeostasis. In the long term, we hope to leverage our understanding of molecular signal transduction to guide the development of new and better therapeutics that modulate these pathways.
Address:
Room SGM - 227
250 Longwood Avenue
Boston, MA 02115
Publications View
Yeast surface display platform for rapid discovery of conformationally selective nanobodies.
Authors: Authors: McMahon C, Baier AS, Pascolutti R, Wegrecki M, Zheng S, Ong JX, Erlandson SC, Hilger D, Rasmussen SGF, Ring AM, Manglik A, Kruse AC.
Nat Struct Mol Biol
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Nat Struct Mol Biol
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Structural Basis for Regulated Proteolysis by the a-Secretase ADAM10.
Authors: Authors: Seegar TCM, Killingsworth LB, Saha N, Meyer PA, Patra D, Zimmerman B, Janes PW, Rubinstein E, Nikolov DB, Skiniotis G, Kruse AC, Blacklow SC.
Cell
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Cell
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Structural Basis for G Protein-Coupled Receptor Activation.
A two-step transport pathway allows the mother cell to nurture the developing spore in Bacillus subtilis.
Authors: Authors: Ramírez-Guadiana FH, Meeske AJ, Rodrigues CDA, Barajas-Ornelas RDC, Kruse AC, Rudner DZ.
PLoS Genet
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PLoS Genet
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Identification of the gene that codes for the s2 receptor.
Authors: Authors: Alon A, Schmidt HR, Wood MD, Sahn JJ, Martin SF, Kruse AC.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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Reevaluation of fenpropimorph as a s receptor ligand: Structure-affinity relationship studies at human s1 receptors.
Authors: Authors: Sguazzini E, Schmidt HR, Iyer KA, Kruse AC, Dukat M.
Bioorg Med Chem Lett
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Bioorg Med Chem Lett
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Multidimensional Tracking of GPCR Signaling via Peroxidase-Catalyzed Proximity Labeling.
Authors: Authors: Paek J, Kalocsay M, Staus DP, Wingler L, Pascolutti R, Paulo JA, Gygi SP, Kruse AC.
Cell
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Cell
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Search for lepton-flavour-violating decays of the Higgs and Z bosons with the ATLAS detector.
Authors: Authors: Aad G, Abbott B, Abdallah J, Abdinov O, Abeloos B, Aben R, Abolins M, AbouZeid OS, Abraham NL, Abramowicz H, Abreu H, Abreu R, Abulaiti Y, Acharya BS, Adamczyk L, Adams DL, Adelman J, Adomeit S, Adye T, Affolder AA, Agatonovic-Jovin T, Agricola J, Aguilar-Saavedra JA, Ahlen SP, Ahmadov F, Aielli G, Akerstedt H, Åkesson TPA, Akimov AV, Alberghi GL, Albert J, Albrand S, Verzini MJA, Aleksa M, Aleksandrov IN, Alexa C, Alexander G, Alexopoulos T, Alhroob M, Aliev M, Alimonti G, Alison J, Alkire SP, Allbrooke BMM, Allen BW, Allport PP, Aloisio A, Alonso A, Alonso F, Alpigiani C, Alstaty M, Gonzalez BA, Piqueras DÁ, Alviggi MG, Amadio BT, Amako K, Coutinho YA, Amelung C, Amidei D, Santos SPAD, Amorim A, Amoroso S, Amundsen G, Anastopoulos C, Ancu LS, Andari N, Andeen T, Anders CF, Anders G, Anders JK, Anderson KJ, Andreazza A, Andrei V, Angelidakis S, Angelozzi I, Anger P, Angerami A, Anghinolfi F, Anisenkov AV, Anjos N, Annovi A, Antonelli M, Antonov A, Antos J, Anulli F, Aoki M, Bella LA, Arabidze G, Arai Y, Araque JP, Arce ATH, Arduh FA, Arguin JF, Argyropoulos S, Arik M, Armbruster AJ, Armitage LJ, Arnaez O, Arnold H, Arratia M, Arslan O, Artamonov A, Artoni G, Artz S, Asai S, Asbah N, Ashkenazi A, Åsman B, Asquith L, Assamagan K, Astalos R, Atkinson M, Atlay NB, Augsten K, Avolio G, Axen B, Ayoub MK, Azuelos G, Baak MA, Baas AE, Baca MJ, Bachacou H, Bachas K, Backes M, Backhaus M, Bagiacchi P, Bagnaia P, Bai Y, Baines JT, Baker OK, Baldin EM, Balek P, Balestri T, Balli F, Balunas WK, Banas E, Banerjee S, Bannoura AAE, Barak L, Barberio EL, Barberis D, Barbero M, Barillari T, Barklow T, Barlow N, Barnes SL, Barnett BM, Barnett RM, Barnovska Z, Baroncelli A, Barone G, Barr AJ, Navarro LB, Barreiro F, da Costa JBG, Bartoldus R, Barton AE, Bartos P, Basalaev A, Bassalat A, Bates RL, Batista SJ, Batley JR, Battaglia M, Bauce M, Bauer F, Bawa HS, Beacham JB, Beattie MD, Beau T, Beauchemin PH, Bechtle P, Beck HP, Becker K, Becker M, Beckingham M, Becot C, Beddall AJ, Beddall A, Bednyakov VA, Bedognetti M, Bee CP, Beemster LJ, Beermann TA, Begel M, Behr JK, Belanger-Champagne C, Bell AS, Bella G, Bellagamba L, Bellerive A, Bellomo M, Belotskiy K, Beltramello O, Belyaev NL, Benary O, Benchekroun D, Bender M, Bendtz K, Benekos N, Benhammou Y, Noccioli EB, Benitez J, Garcia JAB, Benjamin DP, Bensinger JR, Bentvelsen S, Beresford L, Beretta M, Berge D, Kuutmann EB, Berger N, Beringer J, Berlendis S, Bernard NR, Bernius C, Bernlochner FU, Berry T, Berta P, Bertella C, Bertoli G, Bertolucci F, Bertram IA, Bertsche C, Bertsche D, Besjes GJ, Bylund OB, Bessner M, Besson N, Betancourt C, Bethke S, Bevan AJ, Bhimji W, Bianchi RM, Bianchini L, Bianco M, Biebel O, Biedermann D, Bielski R, Biesuz NV, Biglietti M, De Mendizabal JB, Bilokon H, Bindi M, Binet S, Bingul A, Bini C, Biondi S, Bjergaard DM, Black CW, Black JE, Black KM, Blackburn D, Blair RE, Blanchard JB, Blanco JE, Blazek T, Bloch I, Blocker C, Blum W, Blumenschein U, Blunier S, Bobbink GJ, Bobrovnikov VS, Bocchetta SS, Bocci A, Bock C, Boehler M, Boerner D, Bogaerts JA, Bogavac D, Bogdanchikov AG, Bohm C, Boisvert V, Bokan P, Bold T, Boldyrev AS, Bomben M, Bona M, Boonekamp M, Borisov A, Borissov G, Bortfeldt J, Bortoletto D, Bortolotto V, Bos K, Boscherini D, Bosman M, Sola JDB, Boudreau J, Bouffard J, Bouhova-Thacker EV, Boumediene D, Bourdarios C, Boutle SK, Boveia A, Boyd J, Boyko IR, Bracinik J, Brandt A, Brandt G, Brandt O, Bratzler U, Brau B, Brau JE, Braun HM, Madden WDB, Brendlinger K, Brennan AJ, Brenner L, Brenner R, Bressler S, Bristow TM, Britton D, Britzger D, Brochu FM, Brock I, Brock R, Brooijmans G, Brooks T, Brooks WK, Brosamer J, Brost E, Broughton JH, de Renstrom PAB, Bruncko D, Bruneliere R, Bruni A, Bruni G, Brunt BH, Bruschi M, Bruscino N, Bryant P, Bryngemark L, Buanes T, Buat Q, Buchholz P, Buckley AG, Budagov IA, Buehrer F, Bugge MK, Bulekov O, Bullock D, Burckhart H, Burdin S, Burgard CD, Burghgrave B, Burka K, Burke S, Burmeister I, Busato E, et al.
Eur Phys J C Part Fields
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Eur Phys J C Part Fields
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Topological cell clustering in the ATLAS calorimeters and its performance in LHC Run 1.
Authors: Authors: Aad G, Abbott B, Abdallah J, Abdinov O, Aben R, Abolins M, AbouZeid OS, Abramowicz H, Abreu H, Abreu R, Abulaiti Y, Acharya BS, Adamczyk L, Adams DL, Adelman J, Adomeit S, Adye T, Affolder AA, Agatonovic-Jovin T, Agricola J, Aguilar-Saavedra JA, Ahlen SP, Ahmadov F, Aielli G, Akerstedt H, Åkesson TPA, Akimov AV, Alberghi GL, Albert J, Albrand S, Verzini MJA, Aleksa M, Aleksandrov IN, Alexa C, Alexander G, Alexopoulos T, Alhroob M, Alimonti G, Alio L, Alison J, Alkire SP, Allbrooke BMM, Allport PP, Aloisio A, Alonso A, Alonso F, Alpigiani C, Altheimer A, Gonzalez BA, Piqueras DÁ, Alviggi MG, Amadio BT, Amako K, Coutinho YA, Amelung C, Amidei D, Santos SPAD, Amorim A, Amoroso S, Amram N, Amundsen G, Anastopoulos C, Ancu LS, Andari N, Andeen T, Anders CF, Anders G, Anders JK, Anderson KJ, Andreazza A, Andrei V, Angelidakis S, Angelozzi I, Anger P, Angerami A, Anghinolfi F, Anisenkov AV, Anjos N, Annovi A, Antonelli M, Antonov A, Antos J, Anulli F, Aoki M, Bella LA, Arabidze G, Arai Y, Araque JP, Arce ATH, Arduh FA, Arguin JF, Argyropoulos S, Arik M, Armbruster AJ, Arnaez O, Arnold H, Arratia M, Arslan O, Artamonov A, Artoni G, Artz S, Asai S, Asbah N, Ashkenazi A, Åsman B, Asquith L, Assamagan K, Astalos R, Atkinson M, Atlay NB, Augsten K, Aurousseau M, Avolio G, Axen B, Ayoub MK, Azuelos G, Baak MA, Baas AE, Baca MJ, Bacci C, Bachacou H, Bachas K, Backes M, Backhaus M, Bagiacchi P, Bagnaia P, Bai Y, Bain T, Baines JT, Baker OK, Baldin EM, Balek P, Balestri T, Balli F, Balunas WK, Banas E, Banerjee S, Bannoura AAE, Barak L, Barberio EL, Barberis D, Barbero M, Barillari T, Barisonzi M, Barklow T, Barlow N, Barnes SL, Barnett BM, Barnett RM, Barnovska Z, Baroncelli A, Barone G, Barr AJ, Barreiro F, da Costa JBG, Bartoldus R, Barton AE, Bartos P, Basalaev A, Bassalat A, Basye A, Bates RL, Batista SJ, Batley JR, Battaglia M, Bauce M, Bauer F, Bawa HS, Beacham JB, Beattie MD, Beau T, Beauchemin PH, Beccherle R, Bechtle P, Beck HP, Becker K, Becker M, Beckingham M, Becot C, Beddall AJ, Beddall A, Bednyakov VA, Bee CP, Beemster LJ, Beermann TA, Begel M, Behr JK, Belanger-Champagne C, Bell WH, Bella G, Bellagamba L, Bellerive A, Bellomo M, Belotskiy K, Beltramello O, Benary O, Benchekroun D, Bender M, Bendtz K, Benekos N, Benhammou Y, Noccioli EB, Garcia JAB, Benjamin DP, Bensinger JR, Bentvelsen S, Beresford L, Beretta M, Berge D, Kuutmann EB, Berger N, Berghaus F, Beringer J, Bernard C, Bernard NR, Bernius C, Bernlochner FU, Berry T, Berta P, Bertella C, Bertoli G, Bertolucci F, Bertsche C, Bertsche D, Besana MI, Besjes GJ, Bylund OB, Bessner M, Besson N, Betancourt C, Bethke S, Bevan AJ, Bhimji W, Bianchi RM, Bianchini L, Bianco M, Biebel O, Biedermann D, Biesuz NV, Biglietti M, De Mendizabal JB, Bilokon H, Bindi M, Binet S, Bingul A, Bini C, Biondi S, Bjergaard DM, Black CW, Black JE, Black KM, Blackburn D, Blair RE, Blanchard JB, Blanco JE, Blazek T, Bloch I, Blocker C, Blum W, Blumenschein U, Blunier S, Bobbink GJ, Bobrovnikov VS, Bocchetta SS, Bocci A, Bock C, Boehler M, Bogaerts JA, Bogavac D, Bogdanchikov AG, Bohm C, Boisvert V, Bold T, Boldea V, Boldyrev AS, Bomben M, Bona M, Boonekamp M, Borisov A, Borissov G, Borroni S, Bortfeldt J, Bortolotto V, Bos K, Boscherini D, Bosman M, Boudreau J, Bouffard J, Bouhova-Thacker EV, Boumediene D, Bourdarios C, Bousson N, Boutle SK, Boveia A, Boyd J, Boyko IR, Bozic I, Bracinik J, Brandt A, Brandt G, Brandt O, Bratzler U, Brau B, Brau JE, Braun HM, Madden WDB, Brendlinger K, Brennan AJ, Brenner L, Brenner R, Bressler S, Bristow TM, Britton D, Britzger D, Brochu FM, Brock I, Brock R, Bronner J, Brooijmans G, Brooks T, Brooks WK, Brosamer J, Brost E, de Renstrom PAB, Bruncko D, Bruneliere R, Bruni A, Bruni G, Bruschi M, Bruscino N, Bryngemark L, Buanes T, Buat Q, Buchholz P, Buckley AG, Budagov IA, Buehrer F, Bugge L, Bugge MK, Bulekov O, Bullock D, Burckhart H, Burdin S, Burgard CD, Burghgrave B, Burke S, Burmeister I, Busato E, Büscher D, Büscher V, Bussey P, Butler JM, Butt AI, et al.
Eur Phys J C Part Fields
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Eur Phys J C Part Fields
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Measurement of the [Formula: see text] and [Formula: see text] production cross sections in multilepton final states using 3.2 fb[Formula: see text] of [Formula: see text] collisions at [Formula: see text] = 13 TeV with the ATLAS detector.
Authors: Authors: Aaboud M, Aad G, Abbott B, Abdallah J, Abdinov O, Abeloos B, Aben R, AbouZeid OS, Abraham NL, Abramowicz H, Abreu H, Abreu R, Abulaiti Y, Acharya BS, Adamczyk L, Adams DL, Adelman J, Adomeit S, Adye T, Affolder AA, Agatonovic-Jovin T, Agricola J, Aguilar-Saavedra JA, Ahlen SP, Ahmadov F, Aielli G, Akerstedt H, Åkesson TPA, Akimov AV, Alberghi GL, Albert J, Albrand S, Alconada Verzini MJ, Aleksa M, Aleksandrov IN, Alexa C, Alexander G, Alexopoulos T, Alhroob M, Ali B, Aliev M, Alimonti G, Alison J, Alkire SP, Allbrooke BMM, Allen BW, Allport PP, Aloisio A, Alonso A, Alonso F, Alpigiani C, Alstaty M, Alvarez Gonzalez B, Álvarez Piqueras D, Alviggi MG, Amadio BT, Amako K, Amaral Coutinho Y, Amelung C, Amidei D, Amor Dos Santos SP, Amorim A, Amoroso S, Amundsen G, Anastopoulos C, Ancu LS, Andari N, Andeen T, Anders CF, Anders G, Anders JK, Anderson KJ, Andreazza A, Andrei V, Angelidakis S, Angelozzi I, Anger P, Angerami A, Anghinolfi F, Anisenkov AV, Anjos N, Annovi A, Antel C, Antonelli M, Antonov A, Anulli F, Aoki M, Aperio Bella L, Arabidze G, Arai Y, Araque JP, Arce ATH, Arduh FA, Arguin JF, Argyropoulos S, Arik M, Armbruster AJ, Armitage LJ, Arnaez O, Arnold H, Arratia M, Arslan O, Artamonov A, Artoni G, Artz S, Asai S, Asbah N, Ashkenazi A, Åsman B, Asquith L, Assamagan K, Astalos R, Atkinson M, Atlay NB, Augsten K, Avolio G, Axen B, Ayoub MK, Azuelos G, Baak MA, Baas AE, Baca MJ, Bachacou H, Bachas K, Backes M, Backhaus M, Bagiacchi P, Bagnaia P, Bai Y, Baines JT, Baker OK, Baldin EM, Balek P, Balestri T, Balli F, Balunas WK, Banas E, Banerjee S, Bannoura AAE, Barak L, Barberio EL, Barberis D, Barbero M, Barillari T, Barklow T, Barlow N, Barnes SL, Barnett BM, Barnett RM, Barnovska-Blenessy Z, Baroncelli A, Barone G, Barr AJ, Barranco Navarro L, Barreiro F, Barreiro Guimarães da Costa J, Bartoldus R, Barton AE, Bartos P, Basalaev A, Bassalat A, Bates RL, Batista SJ, Batley JR, Battaglia M, Bauce M, Bauer F, Bawa HS, Beacham JB, Beattie MD, Beau T, Beauchemin PH, Bechtle P, Beck HP, Becker K, Becker M, Beckingham M, Becot C, Beddall AJ, Beddall A, Bednyakov VA, Bedognetti M, Bee CP, Beemster LJ, Beermann TA, Begel M, Behr JK, Belanger-Champagne C, Bell AS, Bella G, Bellagamba L, Bellerive A, Bellomo M, Belotskiy K, Beltramello O, Belyaev NL, Benary O, Benchekroun D, Bender M, Bendtz K, Benekos N, Benhammou Y, Benhar Noccioli E, Benitez J, Benjamin DP, Bensinger JR, Bentvelsen S, Beresford L, Beretta M, Berge D, Bergeaas Kuutmann E, Berger N, Beringer J, Berlendis S, Bernard NR, Bernius C, Bernlochner FU, Berry T, Berta P, Bertella C, Bertoli G, Bertolucci F, Bertram IA, Bertsche C, Bertsche D, Besjes GJ, Bessidskaia Bylund O, Bessner M, Besson N, Betancourt C, Bethke S, Bevan AJ, Bhimji W, Bianchi RM, Bianchini L, Bianco M, Biebel O, Biedermann D, Bielski R, Biesuz NV, Biglietti M, De Mendizabal JB, Bilokon H, Bindi M, Binet S, Bingul A, Bini C, Biondi S, Bjergaard DM, Black CW, Black JE, Black KM, Blackburn D, Blair RE, Blanchard JB, Blanco JE, Blazek T, Bloch I, Blocker C, Blum W, Blumenschein U, Blunier S, Bobbink GJ, Bobrovnikov VS, Bocchetta SS, Bocci A, Bock C, Boehler M, Boerner D, Bogaerts JA, Bogavac D, Bogdanchikov AG, Bohm C, Boisvert V, Bokan P, Bold T, Boldyrev AS, Bomben M, Bona M, Boonekamp M, Borisov A, Borissov G, Bortfeldt J, Bortoletto D, Bortolotto V, Bos K, Boscherini D, Bosman M, Bossio Sola JD, Boudreau J, Bouffard J, Bouhova-Thacker EV, Boumediene D, Bourdarios C, Boutle SK, Boveia A, Boyd J, Boyko IR, Bracinik J, Brandt A, Brandt G, Brandt O, Bratzler U, Brau B, Brau JE, Braun HM, Breaden Madden WD, Brendlinger K, Brennan AJ, Brenner L, Brenner R, Bressler S, Bristow TM, Britton D, Britzger D, Brochu FM, Brock I, Brock R, Brooijmans G, Brooks T, Brooks WK, Brosamer J, Brost E, Broughton JH, de Renstrom PAB, Bruncko D, Bruneliere R, Bruni A, Bruni G, Bruni LS, Brunt BH, Bruschi M, Bruscino N, Bryant P, Bryngemark L, Buanes T, Buat Q, Buchholz P, Buckley AG, Budagov IA, Buehrer F, Bugge MK, et al.
Eur Phys J C Part Fields
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Eur Phys J C Part Fields
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