Picture of William Shih
William Shih, Ph.D.
Professor of Biological Chemistry and Molecular Pharmacology

We explore design principles for self-assembling molecular machines. As our model system, we primarily use structural DNA nanotechnology. We seek to apply our knowledge towards construction of artificial systems that help solve problems of biological and medical interest.

Research:

We explore design principles for self-assembling molecular machines. As our model system, we primarily use structural DNA nanotechnology. We seek to apply our knowledge towards construction of artificial systems that help solve problems of biological and medical interest. Currently we focus on building tools for molecular biophysics (macromolecular structure determination and single-molecule assays) and tools for diagnostics and therapeutics (nanoparticle adjuvants for vaccines, drug delivery, tissue engineering). For many applications, our present capabilities are too primitive. Thus we also investigate enabling technologies for increasing the complexity of programmable self-assembled systems.

Address: 

Dana-Farber Cancer Institute

360 Longwood Avenue

Boston, MA 02215

Publications View
In silico Screening and Evaluation of Plasmodium falciparum Protein Kinase 5 (PK5) Inhibitors.
Authors: Authors: Eubanks AL, Perkins MM, Sylvester K, Ganley JG, Posfai D, Sanschargrin PC, Hong J, Sliz P, Derbyshire ER.
ChemMedChem
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mRNA circularization by METTL3-eIF3h enhances translation and promotes oncogenesis.
Authors: Authors: Choe J, Lin S, Zhang W, Liu Q, Wang L, Ramirez-Moya J, Du P, Kim W, Tang S, Sliz P, Santisteban P, George RE, Richards WG, Wong KK, Locker N, Slack FJ, Gregory RI.
Nature
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Small-Molecule Inhibitors Disrupt let-7 Oligouridylation and Release the Selective Blockade of let-7 Processing by LIN28.
Authors: Authors: Wang L, Rowe RG, Jaimes A, Yu C, Nam Y, Pearson DS, Zhang J, Xie X, Marion W, Heffron GJ, Daley GQ, Sliz P.
Cell Rep
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MightyScreen: An Open-Source Visualization Application for Screening Data Analysis.
Authors: Authors: Wang L, Yang Q, Jaimes A, Wang T, Strobelt H, Chen J, Sliz P.
SLAS Discov
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Development of the Precision Link Biobank at Boston Children's Hospital: Challenges and Opportunities.
Authors: Authors: Bourgeois FT, Avillach P, Kong SW, Heinz MM, Tran TA, Chakrabarty R, Bickel J, Sliz P, Borglund EM, Kornetsky S, Mandl KD.
J Pers Med
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Comparative analysis of LIN28-RNA binding sites identified at single nucleotide resolution.
Authors: Authors: Ransey E, Björkbom A, Lelyveld VS, Biecek P, Pantano L, Szostak JW, Sliz P.
RNA Biol
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LIN28 Zinc Knuckle Domain Is Required and Sufficient to Induce let-7 Oligouridylation.
Authors: Authors: Wang L, Nam Y, Lee AK, Yu C, Roth K, Chen C, Ransey EM, Sliz P.
Cell Rep
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Cryo-EM structure of the replisome reveals multiple interactions coordinating DNA synthesis.
Authors: Authors: Kulczyk AW, Moeller A, Meyer P, Sliz P, Richardson CC.
Proc Natl Acad Sci U S A
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STK40 Is a Pseudokinase that Binds the E3 Ubiquitin Ligase COP1.
Authors: Authors: Durzynska I, Xu X, Adelmant G, Ficarro SB, Marto JA, Sliz P, Uljon S, Blacklow SC.
Structure
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Extension of research data repository system to support direct compute access to biomedical datasets: enhancing Dataverse to support large datasets.
Authors: Authors: McKinney B, Meyer PA, Crosas M, Sliz P.
Ann N Y Acad Sci
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