HMS placeholder

Shamil R. Sunyaev, Ph.D.

Professor of Medicine
617-525-6675
Publications View
Exome sequencing and the genetic basis of complex traits.
Authors: Authors: Kiezun A, Garimella K, Do R, Stitziel NO, Neale BM, McLaren PJ, Gupta N, Sklar P, Sullivan PF, Moran JL, Hultman CM, Lichtenstein P, Magnusson P, Lehner T, Shugart YY, Price AL, de Bakker PI, Purcell SM, Sunyaev SR.
Nat Genet
View full abstract on Pubmed
Extremely low-coverage sequencing and imputation increases power for genome-wide association studies.
Authors: Authors: Pasaniuc B, Rohland N, McLaren PJ, Garimella K, Zaitlen N, Li H, Gupta N, Neale BM, Daly MJ, Sklar P, Sullivan PF, Bergen S, Moran JL, Hultman CM, Lichtenstein P, Magnusson P, Purcell SM, Haas DW, Liang L, Sunyaev S, Patterson N, de Bakker PI, Reich D, Price AL.
Nat Genet
View full abstract on Pubmed
Patterns and rates of exonic de novo mutations in autism spectrum disorders.
Authors: Authors: Neale BM, Kou Y, Liu L, Ma'ayan A, Samocha KE, Sabo A, Lin CF, Stevens C, Wang LS, Makarov V, Polak P, Yoon S, Maguire J, Crawford EL, Campbell NG, Geller ET, Valladares O, Schafer C, Liu H, Zhao T, Cai G, Lihm J, Dannenfelser R, Jabado O, Peralta Z, Nagaswamy U, Muzny D, Reid JG, Newsham I, Wu Y, Lewis L, Han Y, Voight BF, Lim E, Rossin E, Kirby A, Flannick J, Fromer M, Shakir K, Fennell T, Garimella K, Banks E, Poplin R, Gabriel S, DePristo M, Wimbish JR, Boone BE, Levy SE, Betancur C, Sunyaev S, Boerwinkle E, Buxbaum JD, Cook EH, Devlin B, Gibbs RA, Roeder K, Schellenberg GD, Sutcliffe JS, Daly MJ.
Nature
View full abstract on Pubmed
Genome-wide association study reveals class I MHC-restricted T cell-associated molecule gene (CRTAM) variants interact with vitamin D levels to affect asthma exacerbations.
Authors: Authors: Du R, Litonjua AA, Tantisira KG, Lasky-Su J, Sunyaev SR, Klanderman BJ, Celedón JC, Avila L, Soto-Quiros ME, Weiss ST.
J Allergy Clin Immunol
View full abstract on Pubmed
The mystery of missing heritability: Genetic interactions create phantom heritability.
Authors: Authors: Zuk O, Hechter E, Sunyaev SR, Lander ES.
Proc Natl Acad Sci U S A
View full abstract on Pubmed
Genome sequencing reveals insights into physiology and longevity of the naked mole rat.
Authors: Authors: Kim EB, Fang X, Fushan AA, Huang Z, Lobanov AV, Han L, Marino SM, Sun X, Turanov AA, Yang P, Yim SH, Zhao X, Kasaikina MV, Stoletzki N, Peng C, Polak P, Xiong Z, Kiezun A, Zhu Y, Chen Y, Kryukov GV, Zhang Q, Peshkin L, Yang L, Bronson RT, Buffenstein R, Wang B, Han C, Li Q, Chen L, Zhao W, Sunyaev SR, Park TJ, Zhang G, Wang J, Gladyshev VN.
Nature
View full abstract on Pubmed
Computational and statistical approaches to analyzing variants identified by exome sequencing.
Authors: Authors: Stitziel NO, Kiezun A, Sunyaev S.
Genome Biol
View full abstract on Pubmed
Progressive multifocal leukoencephalopathy (PML) development is associated with mutations in JC virus capsid protein VP1 that change its receptor specificity.
Authors: Authors: Gorelik L, Reid C, Testa M, Brickelmaier M, Bossolasco S, Pazzi A, Bestetti A, Carmillo P, Wilson E, McAuliffe M, Tonkin C, Carulli JP, Lugovskoy A, Lazzarin A, Sunyaev S, Simon K, Cinque P.
J Infect Dis
View full abstract on Pubmed
Assigning spectrum-specific P-values to protein identifications by mass spectrometry.
Authors: Authors: Spirin V, Shpunt A, Seebacher J, Gentzel M, Shevchenko A, Gygi S, Sunyaev S.
Bioinformatics
View full abstract on Pubmed
Development and validation of a computational method for assessment of missense variants in hypertrophic cardiomyopathy.
Authors: Authors: Jordan DM, Kiezun A, Baxter SM, Agarwala V, Green RC, Murray MF, Pugh T, Lebo MS, Rehm HL, Funke BH, Sunyaev SR.
Am J Hum Genet
View full abstract on Pubmed