Shamil R. Sunyaev

Shamil R. Sunyaev, Ph.D.

Professor of Medicine

617-525-6675

Publications

Publications View

Mutational heterogeneity in cancer and the search for new cancer-associated genes.

Authors: Authors: Lawrence MS, Stojanov P, Polak P, Kryukov GV, Cibulskis K, Sivachenko A, Carter SL, Stewart C, Mermel CH, Roberts SA, Kiezun A, Hammerman PS, McKenna A, Drier Y, Zou L, Ramos AH, Pugh TJ, Stransky N, Helman E, Kim J, Sougnez C, Ambrogio L, Nickerson E, Shefler E, Cortés ML, Auclair D, Saksena G, Voet D, Noble M, DiCara D, Lin P, Lichtenstein L, Heiman DI, Fennell T, Imielinski M, Hernandez B, Hodis E, Baca S, Dulak AM, Lohr J, Landau DA, Wu CJ, Melendez-Zajgla J, Hidalgo-Miranda A, Koren A, McCarroll SA, Mora J, Crompton B, Onofrio R, Parkin M, Winckler W, Ardlie K, Gabriel SB, Roberts CWM, Biegel JA, Stegmaier K, Bass AJ, Garraway LA, Meyerson M, Golub TR, Gordenin DA, Sunyaev S, Lander ES, Getz G.
Nature 2013-07-11
View full abstract on Pubmed

Sequencing studies in human genetics: design and interpretation.

Authors: Authors: Goldstein DB, Allen A, Keebler J, Margulies EH, Petrou S, Petrovski S, Sunyaev S.
Nat Rev Genet 2013-07-01
View full abstract on Pubmed

Balancing selection on a regulatory region exhibiting ancient variation that predates human-neandertal divergence.

Authors: Authors: Gokcumen O, Zhu Q, Mulder LC, Iskow RC, Austermann C, Scharer CD, Raj T, Boss JM, Sunyaev S, Price A, Stranger B, Simon V, Lee C.
PLoS Genet 2013-04-01
View full abstract on Pubmed

Gain-of-function mutations in the mechanically activated ion channel PIEZO2 cause a subtype of Distal Arthrogryposis.

Authors: Authors: Coste B, Houge G, Murray MF, Stitziel N, Bandell M, Giovanni MA, Philippakis A, Hoischen A, Riemer G, Steen U, Steen VM, Mathur J, Cox J, Lebo M, Rehm H, Weiss ST, Wood JN, Maas RL, Sunyaev SR, Patapoutian A.
Proc Natl Acad Sci U S A 2013-03-19
View full abstract on Pubmed

Impact of deleterious passenger mutations on cancer progression.

Authors: Authors: McFarland CD, Korolev KS, Kryukov GV, Sunyaev SR, Mirny LA.
Proc Natl Acad Sci U S A 2013-02-19
View full abstract on Pubmed

Rare, low-frequency, and common variants in the protein-coding sequence of biological candidate genes from GWASs contribute to risk of rheumatoid arthritis.

Authors: Authors: Diogo D, Kurreeman F, Stahl EA, Liao KP, Gupta N, Greenberg JD, Rivas MA, Hickey B, Flannick J, Thomson B, Guiducci C, Ripke S, Adzhubey I, Barton A, Kremer JM, Alfredsson L, Sunyaev S, Martin J, Zhernakova A, Bowes J, Eyre S, Siminovitch KA, Gregersen PK, Worthington J, Klareskog L, Padyukov L, Raychaudhuri S, Plenge RM.
Am J Hum Genet 2013-01-10
View full abstract on Pubmed

Genomic variation landscape of the human gut microbiome.

Authors: Authors: Schloissnig S, Arumugam M, Sunagawa S, Mitreva M, Tap J, Zhu A, Waller A, Mende DR, Kultima JR, Martin J, Kota K, Sunyaev SR, Weinstock GM, Bork P.
Nature 2013-01-03
View full abstract on Pubmed

Predicting functional effect of human missense mutations using PolyPhen-2.

Authors: Authors: Adzhubei I, Jordan DM, Sunyaev SR.
Curr Protoc Hum Genet 2013-01-01
View full abstract on Pubmed

Individuality and temporal stability of the human gut microbiome.

Authors: Authors: Sunagawa S, Schloissnig S, Arumugam M, Forslund K, Mitreva M, Tap J, Zhu A, Waller A, Mende DR, Kultima JR, Martin J, Kota K, Sunyaev SR, Typas A, Weinstock GM, Bork P.
Cent Asian J Glob Health 2013-01-01
View full abstract on Pubmed

Genome analysis reveals insights into physiology and longevity of the Brandt's bat Myotis brandtii.

Authors: Authors: Seim I, Fang X, Xiong Z, Lobanov AV, Huang Z, Ma S, Feng Y, Turanov AA, Zhu Y, Lenz TL, Gerashchenko MV, Fan D, Hee Yim S, Yao X, Jordan D, Xiong Y, Ma Y, Lyapunov AN, Chen G, Kulakova OI, Sun Y, Lee SG, Bronson RT, Moskalev AA, Sunyaev SR, Zhang G, Krogh A, Wang J, Gladyshev VN.
Nat Commun 2013-01-01
View full abstract on Pubmed