Picture of Jon Clardy

Jon Clardy, Ph.D.

Christopher T. Walsh Professor of Biological Chemistry and Molecular Pharmacology

The laboratory focuses on biologically active small molecules, especially those from bacteria and fungi with an overall goal of understanding how small molecules control biological processes. 

Research:

The laboratory focuses on biologically active small molecules, especially those from bacteria and fungi with an overall goal of understanding how small molecules control biological processes.  Organizing themes include: 1) function-based discovery of microbially-produced small molecules and their roles in microbial symbioses , 2) function-based discovery of biologically active small molecules using high-throughput screening,  3) genome-based discovery of bacterially-produced small molecules. 

1.  We have focused on the small molecule exchanges that underlie multilateral symbioses involving bacteria, partly because they are widespread and poorly understood and partly because they lead to the discovery of new useful molecules in the biological context in which they evolved.  Current projects involve the bacterial symbionts of fungus-growing ants, members of the human gut microbiome linked to disease, and interactions between micro-algae and bacteria.

2.  We also continue to discover small molecules in a more medically relevant context: high-throughput screening for a variety of diseases.  In these projects we have focused on antibacterial, antifungal, and antiparasitic agents along with immunomodulators and anticancer agents. 

3.  It is now quite clear that well studied bacteria – the producers of drugs that are used on the ton scale, for example – are genetically capable of producing many more potentially useful small molecules.  The biosynthetic gene can be seen but the associated molecules have never been characterized.  Ways to access these cryptic metabolites is a current focus of the laboratory.

Address: 

Room C-643

240 Longwood Avenue

Boston, MA 02115

Publications View
3H-Cyclonona[def]biphenylene. An example of neutral homoantiaromaticity.
Authors: Authors: Wilcox CF, Blain DA, Clardy J, Van Duyne G, Gleiter R, Eckert-Maksic M.
J Am Chem Soc
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PD 116,152, a new phenazine antitumor antibiotic. Structure and antitumor activity.
Authors: Authors: Smitka TA, Bunge RH, Wilton JH, Hokanson GC, French JC, He CH, Clardy J.
J Antibiot (Tokyo)
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Pentacyclo[12.2.2.22,5.26,9.210,13]-1,5,9,13-tetracosatetraene and its reaction with silver trifluoromethanesulfonate. Synthesis of a square-planar d10 organometallic complex.
Authors: Authors: McMurry JE, Haley GJ, Matz JR, Clardy JC, Mitchell J.
J Am Chem Soc
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Structure of brevetoxin A (GB-1 toxin), the most potent toxin in the Florida red tide organism Gymnodinium breve (Ptychodiscus brevis).
Authors: Authors: Shimizu Y, Chou HN, Bando H, Van Duyne G, Clardy J.
J Am Chem Soc
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Bipolaroxin, a selective phytotoxin produced by Bipolaris cynodontis.
Authors: Authors: Sugawara F, Strobel G, Fisher LE, Van Duyne GD, Clardy J.
Proc Natl Acad Sci U S A
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Phytoecdysteroids of Diploclisia glaucescens Seed.
Authors: Authors: Miller RW, Clardy J, Kozlowski J, Mikolajczak KL, Plattner RD, Powell RG, Smith CR, Weisleder D, Qi-Tai Z.
Planta Med
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Phytoecdysteroids of Diploclisia glaucescens seed.
Authors: Authors: Miller RW, Clardy J, Kozlowski J, Mikolajczak KL, Plattner RD, Powell RG, Smith CR, Weisleder D, Zheng QT.
Planta Med
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A new monoterpene glycoside of Paeonia lactiflora.
Authors: Authors: Lang HY, Li SZ, McCabe T, Clardy J.
Planta Med
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A new naphthaquinone antibiotic from a new species of yeast.
Authors: Authors: Flegel TW, Meevootisom V, Thebtaranonth Y, Qi-Tai Z, Clardy J.
J Antibiot (Tokyo)
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Absolute stereochemistry and dopaminergic activity of enantiomers of 2,3,4,5-tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine.
Authors: Authors: Kaiser C, Dandridge PA, Garvey E, Hahn RA, Sarau HM, Setler PE, Bass LS, Clardy J.
J Med Chem
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