Picture of Jon Clardy
Jon Clardy, Ph.D.
Hsien Wu and Daisy Yen Wu Professor of Biological Chemistry and Molecular Pharmacology

The laboratory focuses on biologically active small molecules, especially those from bacteria and fungi with an overall goal of understanding how small molecules control biological processes. 

 

Research:

The laboratory focuses on biologically active small molecules, especially those from bacteria and fungi with an overall goal of understanding how small molecules control biological processes.  Organizing themes include: 1) function-based discovery of microbially-produced small molecules and their roles in microbial symbioses , 2) function-based discovery of biologically active small molecules using high-throughput screening,  3) genome-based discovery of bacterially-produced small molecules. 

1.  We have focused on the small molecule exchanges that underlie multilateral symbioses involving bacteria, partly because they are widespread and poorly understood and partly because they lead to the discovery of new useful molecules in the biological context in which they evolved.  Current projects involve the bacterial symbionts of fungus-growing ants, members of the human gut microbiome linked to disease, and interactions between micro-algae and bacteria.

2.  We also continue to discover small molecules in a more medically relevant context: high-throughput screening for a variety of diseases.  In these projects we have focused on antibacterial, antifungal, and antiparasitic agents along with immunomodulators and anticancer agents. 

3.  It is now quite clear that well studied bacteria – the producers of drugs that are used on the ton scale, for example – are genetically capable of producing many more potentially useful small molecules.  The biosynthetic gene can be seen but the associated molecules have never been characterized.  Ways to access these cryptic metabolites is a current focus of the laboratory.

Address: 

Room C-643

240 Longwood Avenue

Boston, MA 02115

Publications View
Neuronal control of maternal provisioning in response to social cues.
Authors: Authors: Wasson JA, Harris G, Keppler-Ross S, Brock TJ, Dar AR, Butcher RA, Fischer SEJ, Kagias K, Clardy J, Zhang Y, Mango SE.
Sci Adv
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A Machine Learning Bioinformatics Method to Predict Biological Activity from Biosynthetic Gene Clusters.
Authors: Authors: Walker AS, Clardy J.
J Chem Inf Model
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Capsular polysaccharide correlates with immune response to the human gut microbe Ruminococcus gnavus.
Authors: Authors: Henke MT, Brown EM, Cassilly CD, Vlamakis H, Xavier RJ, Clardy J.
Proc Natl Acad Sci U S A
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Burkholderia from fungus gardens of fungus-growing ants produce antifungals that inhibit the specialized parasite Escovopsis.
Authors: Authors: Francoeur CB, May DS, Thairu MW, Hoang DQ, Panthofer O, Bugni TS, Pupo MT, Clardy J, Pinto-Tomás AA, Currie CR.
Appl Environ Microbiol
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Specialized Metabolites Reveal Evolutionary History and Geographic Dispersion of a Multilateral Symbiosis.
Authors: Authors: Fukuda TTH, Helfrich EJN, Mevers E, Melo WGP, Van Arnam EB, Andes DR, Currie CR, Pupo MT, Clardy J.
ACS Cent Sci
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Bacterial diketopiperazines stimulate diatom growth and lipid accumulation.
Authors: Authors: Sittmann J, Bae M, Mevers E, Li M, Quinn A, Sriram G, Clardy J, Liu Z.
Plant Physiol
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Chemical Exchanges between Multilateral Symbionts.
Authors: Authors: Bae M, Mevers E, Pishchany G, Whaley SG, Rock CO, Andes DR, Currie CR, Pupo MT, Clardy J.
Org Lett
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Pollen Streptomyces Produce Antibiotic That Inhibits the Honey Bee Pathogen Paenibacillus larvae.
Authors: Authors: Grubbs KJ, May DS, Sardina JA, Dermenjian RK, Wyche TP, Pinto-Tomás AA, Clardy J, Currie CR.
Front Microbiol
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Plasmalogen Biosynthesis by Anaerobic Bacteria: Identification of a Two-Gene Operon Responsible for Plasmalogen Production in Clostridium perfringens.
Authors: Authors: Jackson DR, Cassilly CD, Plichta DR, Vlamakis H, Liu H, Melville SB, Xavier RJ, Clardy J.
ACS Chem Biol
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Enteroendocrine cells sense bacterial tryptophan catabolites to activate enteric and vagal neuronal pathways.
Authors: Authors: Ye L, Bae M, Cassilly CD, Jabba SV, Thorpe DW, Martin AM, Lu HY, Wang J, Thompson JD, Lickwar CR, Poss KD, Keating DJ, Jordt SE, Clardy J, Liddle RA, Rawls JF.
Cell Host Microbe
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