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Dominic M. Walsh, Ph.D.

Lecturer on Neurology
617-525-5059
Publications View
Dynamics of plasma biomarkers in Down syndrome: the relative levels of Aß42 decrease with age, whereas NT1 tau and NfL increase.
Authors: Authors: Mengel D, Liu W, Glynn RJ, Selkoe DJ, Strydom A, Lai F, Rosas HD, Torres A, Patsiogiannis V, Skotko B, Walsh DM.
Alzheimers Res Ther
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PrP is a central player in toxicity mediated by soluble aggregates of neurodegeneration-causing proteins.
Authors: Authors: Corbett GT, Wang Z, Hong W, Colom-Cadena M, Rose J, Liao M, Asfaw A, Hall TC, Ding L, DeSousa A, Frosch MP, Collinge J, Harris DA, Perkinton MS, Spires-Jones TL, Young-Pearse TL, Billinton A, Walsh DM.
Acta Neuropathol
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A vicious cycle of ß amyloid-dependent neuronal hyperactivation.
Authors: Authors: Zott B, Simon MM, Hong W, Unger F, Chen-Engerer HJ, Frosch MP, Sakmann B, Walsh DM, Konnerth A.
Science
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Target engagement in an alzheimer trial: Crenezumab lowers amyloid ß oligomers in cerebrospinal fluid.
Authors: Authors: Yang T, Dang Y, Ostaszewski B, Mengel D, Steffen V, Rabe C, Bittner T, Walsh DM, Selkoe DJ.
Ann Neurol
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Soluble tau aggregates inhibit synaptic long-term depression and amyloid ß-facilitated LTD in vivo.
Authors: Authors: Ondrejcak T, Hu NW, Qi Y, Klyubin I, Corbett GT, Fraser G, Perkinton MS, Walsh DM, Billinton A, Rowan MJ.
Neurobiol Dis
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Identification of neurotoxic cross-linked amyloid-ß dimers in the Alzheimer's brain.
Authors: Authors: Brinkmalm G, Hong W, Wang Z, Liu W, O'Malley TT, Sun X, Frosch MP, Selkoe DJ, Portelius E, Zetterberg H, Blennow K, Walsh DM.
Brain
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PrP-grafted antibodies bind certain amyloid ß-protein aggregates, but do not prevent toxicity.
Authors: Authors: Mengel D, Hong W, Corbett GT, Liu W, DeSousa A, Solforosi L, Fang C, Frosch MP, Collinge J, Harris DA, Walsh DM.
Brain Res
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Learnings about the complexity of extracellular tau aid development of a blood-based screen for Alzheimer's disease.
Authors: Authors: Chen Z, Mengel D, Keshavan A, Rissman RA, Billinton A, Perkinton M, Percival-Alwyn J, Schultz A, Properzi M, Johnson K, Selkoe DJ, Sperling RA, Patel P, Zetterberg H, Galasko D, Schott JM, Walsh DM.
Alzheimers Dement
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miR-212 and miR-132 Are Downregulated in Neurally Derived Plasma Exosomes of Alzheimer's Patients.
Authors: Authors: Cha DJ, Mengel D, Mustapic M, Liu W, Selkoe DJ, Kapogiannis D, Galasko D, Rissman RA, Bennett DA, Walsh DM.
Front Neurosci
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Cellular Prion Protein Mediates the Disruption of Hippocampal Synaptic Plasticity by Soluble Tau In Vivo.
Authors: Authors: Ondrejcak T, Klyubin I, Corbett GT, Fraser G, Hong W, Mably AJ, Gardener M, Hammersley J, Perkinton MS, Billinton A, Walsh DM, Rowan MJ.
J Neurosci
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