Publications View
Laying the foundations of programmed cell death.
Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members.
Authors: Authors: Certo M, Del Gaizo Moore V, Nishino M, Wei G, Korsmeyer S, Armstrong SA, Letai A.
Cancer Cell
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Cancer Cell
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Growth factor withdrawal and apoptosis: the middle game.
A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib.
Authors: Authors: Chauhan D, Catley L, Li G, Podar K, Hideshima T, Velankar M, Mitsiades C, Mitsiades N, Yasui H, Letai A, Ovaa H, Berkers C, Nicholson B, Chao TH, Neuteboom ST, Richardson P, Palladino MA, Anderson KC.
Cancer Cell
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Cancer Cell
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BCL-2: found bound and drugged!
Pharmacological manipulation of Bcl-2 family members to control cell death.
An inhibitor of Bcl-2 family proteins induces regression of solid tumours.
Authors: Authors: Oltersdorf T, Elmore SW, Shoemaker AR, Armstrong RC, Augeri DJ, Belli BA, Bruncko M, Deckwerth TL, Dinges J, Hajduk PJ, Joseph MK, Kitada S, Korsmeyer SJ, Kunzer AR, Letai A, Li C, Mitten MJ, Nettesheim DG, Ng S, Nimmer PM, O'Connor JM, Oleksijew A, Petros AM, Reed JC, Shen W, Tahir SK, Thompson CB, Tomaselli KJ, Wang B, Wendt MD, Zhang H, Fesik SW, Rosenberg SH.
Nature
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Nature
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Antiapoptotic BCL-2 is required for maintenance of a model leukemia.
Authors: Authors: Letai A, Sorcinelli MD, Beard C, Korsmeyer SJ.
Cancer Cell
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Cancer Cell
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Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1.
Authors: Authors: Opferman JT, Letai A, Beard C, Sorcinelli MD, Ong CC, Korsmeyer SJ.
Nature
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Nature
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Smallpox and smallpox vaccination.