Publications View
Parkin selectively alters the intrinsic threshold for mitochondrial cytochrome c release.
Authors: Authors: Berger AK, Cortese GP, Amodeo KD, Weihofen A, Letai A, LaVoie MJ.
Hum Mol Genet
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Hum Mol Genet
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MCL-1-dependent leukemia cells are more sensitive to chemotherapy than BCL-2-dependent counterparts.
Authors: Authors: Brunelle JK, Ryan J, Yecies D, Opferman JT, Letai A.
J Cell Biol
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J Cell Biol
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Aurora kinase A is a target of Wnt/beta-catenin involved in multiple myeloma disease progression.
Authors: Authors: Dutta-Simmons J, Zhang Y, Gorgun G, Gatt M, Mani M, Hideshima T, Takada K, Carlson NE, Carrasco DE, Tai YT, Raje N, Letai AG, Anderson KC, Carrasco DR.
Blood
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Blood
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Hiding from ABT-737 in lymph nodes.
Puma strikes Bax.
Control of mitochondrial apoptosis by the Bcl-2 family.
Mimicking the BH3 domain to kill cancer cells.
Alteration of the mitochondrial apoptotic pathway is key to acquired paclitaxel resistance and can be reversed by ABT-737.
BIM and other BCL-2 family proteins exhibit cross-species conservation of function between zebrafish and mammals.
Authors: Authors: Jette CA, Flanagan AM, Ryan J, Pyati UJ, Carbonneau S, Stewart RA, Langenau DM, Look AT, Letai A.
Cell Death Differ
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Cell Death Differ
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BH3 domains define selective inhibitory interactions with BHRF-1 and KSHV BCL-2.