Picture of Andrew Kruse

Andrew Kruse, Ph.D.

Professor of Biological Chemistry and Molecular Pharmacology
617-432-3252
Kruse lab website

Our research aims to elucidate the molecular basis of membrane protein signaling using techniques including protein engineering, structural biology, and pharmacology.

Research:

Signal transduction across cell membranes plays a central role in human physiology and disease, yet the mechanistic details underlying transmembrane signaling remain poorly understood. Our research aims to elucidate the molecular basis of membrane protein signaling using techniques including protein engineering, structural biology, and pharmacology. In particular, we are focused on the study of proteins important in human health and disease, including G protein-coupled receptors and other proteins that regulate neurotransmission and metabolic homeostasis.

G protein-coupled receptors (GPCRs) are cell-surface receptors that regulate neurotransmission, cardiovascular function, metabolic homeostasis, and many other physiological processes. Due to their central role in human physiology, these receptors are among the most important targets of therapeutic drugs, and are they among the most extensively studied proteins. To better understand GPCR signal transduction at a molecular level, we are using structural biology and biophysical methods to study model GPCRs such as muscarinic acetylcholine receptors. In addition, we are using new approaches in combinatorial biology to facilitate structural studies and to create protein ligands of GPCRs.

We are also interested in signal transduction pathways that remain less extensively studied than GPCRs, particularly receptors involved in the regulation of human metabolic homeostasis. In the long term, we hope to leverage our understanding of molecular signal transduction to guide the development of new and better therapeutics that modulate these pathways.

Address: 

Room SGM - 227

250 Longwood Avenue

Boston, MA 02115

Publications View
Measurement of jet shapes in top-quark pair events at [Formula: see text] using the ATLAS detector.
Authors: Authors: Aad G, Abajyan T, Abbott B, Abdallah J, Abdel Khalek S, Abdelalim AA, Abdinov O, Aben R, Abi B, Abolins M, AbouZeid OS, Abramowicz H, Abreu H, Abulaiti Y, Acharya BS, Adamczyk L, Adams DL, Addy TN, Adelman J, Adomeit S, Adye T, Aefsky S, Agatonovic-Jovin T, Aguilar-Saavedra JA, Agustoni M, Ahlen SP, Ahles F, Ahmad A, Ahsan M, Aielli G, Åkesson TP, Akimoto G, Akimov AV, Alam MA, Albert J, Albrand S, Alconada Verzini MJ, Aleksa M, Aleksandrov IN, Alessandria F, Alexa C, Alexander G, Alexandre G, Alexopoulos T, Alhroob M, Aliev M, Alimonti G, Alison J, Allbrooke BM, Allison LJ, Allport PP, Allwood-Spiers SE, Almond J, Aloisio A, Alon R, Alonso A, Alonso F, Altheimer A, Alvarez Gonzalez B, Alviggi MG, Amako K, Amaral Coutinho Y, Amelung C, Ammosov VV, Amor Dos Santos SP, Amorim A, Amoroso S, Amram N, Anastopoulos C, Ancu LS, Andari N, Andeen T, Anders CF, Anders G, Anderson KJ, Andreazza A, Andrei V, Anduaga XS, Angelidakis S, Anger P, Angerami A, Anghinolfi F, Anisenkov AV, Anjos N, Annovi A, Antonaki A, Antonelli M, Antonov A, Antos J, Anulli F, Aoki M, Aperio Bella L, Apolle R, Arabidze G, Aracena I, Arai Y, Arce AT, Arfaoui S, Arguin JF, Argyropoulos S, Arik E, Arik M, Armbruster AJ, Arnaez O, Arnal V, Artamonov A, Artoni G, Arutinov D, Asai S, Asbah N, Ask S, Åsman B, Asquith L, Assamagan K, Astalos R, Astbury A, Atkinson M, Auerbach B, Auge E, Augsten K, Aurousseau M, Avolio G, Axen D, Azuelos G, Azuma Y, Baak MA, Baccaglioni G, Bacci C, Bach AM, Bachacou H, Bachas K, Backes M, Backhaus M, Backus Mayes J, Badescu E, Bagiacchi P, Bagnaia P, Bai Y, Bailey DC, Bain T, Baines JT, Baker OK, Baker S, Balek P, Balli F, Banas E, Banerjee P, Banerjee S, Banfi D, Bangert A, Bansal V, Bansil HS, Barak L, Baranov SP, Barber T, Barberio EL, Barberis D, Barbero M, Bardin DY, Barillari T, Barisonzi M, Barklow T, Barlow N, Barnett BM, Barnett RM, Baroncelli A, Barone G, Barr AJ, Barreiro F, Barreiro Guimarães da Costa J, Bartoldus R, Barton AE, Bartsch V, Basye A, Bates RL, Batkova L, Batley JR, Battaglia A, Battistin M, Bauer F, Bawa HS, Beale S, Beau T, Beauchemin PH, Beccherle R, Bechtle P, Beck HP, Becker K, Becker S, Beckingham M, Becks KH, Beddall AJ, Beddall A, Bedikian S, Bednyakov VA, Bee CP, Beemster LJ, Beermann TA, Begel M, Belanger-Champagne C, Bell PJ, Bell WH, Bella G, Bellagamba L, Bellerive A, Bellomo M, Belloni A, Beloborodova OL, Belotskiy K, Beltramello O, Benary O, Benchekroun D, Bendtz K, Benekos N, Benhammou Y, Benhar Noccioli E, Benitez Garcia JA, Benjamin DP, Bensinger JR, Benslama K, Bentvelsen S, Berge D, Bergeaas Kuutmann E, Berger N, Berghaus F, Berglund E, Beringer J, Bernat P, Bernhard R, Bernius C, Bernlochner FU, Berry T, Bertella C, Bertolucci F, Besana MI, Besjes GJ, Besson N, Bethke S, Bhimji W, Bianchi RM, Bianchini L, Bianco M, Biebel O, Bieniek SP, Bierwagen K, Biesiada J, Biglietti M, Bilokon H, Bindi M, Binet S, Bingul A, Bini C, Bittner B, Black CW, Black JE, Black KM, Blackburn D, Blair RE, Blanchard JB, Blazek T, Bloch I, Blocker C, Blocki J, Blum W, Blumenschein U, Bobbink GJ, Bobrovnikov VS, Bocchetta SS, Bocci A, Boddy CR, Boehler M, Boek J, Boek TT, Boelaert N, Bogaerts JA, Bogdanchikov AG, Bogouch A, Bohm C, Bohm J, Boisvert V, Bold T, Boldea V, Bolnet NM, Bomben M, Bona M, Boonekamp M, Bordoni S, Borer C, Borisov A, Borissov G, Borri M, Borroni S, Bortfeldt J, Bortolotto V, Bos K, Boscherini D, Bosman M, Boterenbrood H, Bouchami J, Boudreau J, Bouhova-Thacker EV, Boumediene D, Bourdarios C, Bousson N, Boutouil S, Boveia A, Boyd J, Boyko IR, Bozovic-Jelisavcic I, Bracinik J, Branchini P, Brandt A, Brandt G, Brandt O, Bratzler U, Brau B, Brau JE, Braun HM, Brazzale SF, Brelier B, Bremer J, Brendlinger K, Brenner R, Bressler S, Bristow TM, Britton D, Brochu FM, Brock I, Brock R, Broggi F, Bromberg C, Bronner J, Brooijmans G, Brooks T, Brooks WK, Brown G, Bruckman de Renstrom PA, Bruncko D, Bruneliere R, Brunet S, Bruni A, Bruni G, Bruschi M, Bryngemark L, Buanes T, Buat Q, Bucci F, et al.
Eur Phys J C Part Fields
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A new class of amphiphiles bearing rigid hydrophobic groups for solubilization and stabilization of membrane proteins.
Authors: Authors: Chae PS, Rasmussen SG, Rana RR, Gotfryd K, Kruse AC, Manglik A, Cho KH, Nurva S, Gether U, Guan L, Loland CJ, Byrne B, Kobilka BK, Gellman SH.
Chemistry
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Structure of the d-opioid receptor bound to naltrindole.
Authors: Authors: Granier S, Manglik A, Kruse AC, Kobilka TS, Thian FS, Weis WI, Kobilka BK.
Nature
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Crystal structure of the µ-opioid receptor bound to a morphinan antagonist.
Authors: Authors: Manglik A, Kruse AC, Kobilka TS, Thian FS, Mathiesen JM, Sunahara RK, Pardo L, Weis WI, Kobilka BK, Granier S.
Nature
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Structure and dynamics of the M3 muscarinic acetylcholine receptor.
Authors: Authors: Kruse AC, Hu J, Pan AC, Arlow DH, Rosenbaum DM, Rosemond E, Green HF, Liu T, Chae PS, Dror RO, Shaw DE, Weis WI, Wess J, Kobilka BK.
Nature
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Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist.
Authors: Authors: Haga K, Kruse AC, Asada H, Yurugi-Kobayashi T, Shiroishi M, Zhang C, Weis WI, Okada T, Kobilka BK, Haga T, Kobayashi T.
Nature
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T cell receptor signaling is limited by docking geometry to peptide-major histocompatibility complex.
Authors: Authors: Adams JJ, Narayanan S, Liu B, Birnbaum ME, Kruse AC, Bowerman NA, Chen W, Levin AM, Connolly JM, Zhu C, Kranz DM, Garcia KC.
Immunity
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Crystal structure of the ß2 adrenergic receptor-Gs protein complex.
Authors: Authors: Rasmussen SG, DeVree BT, Zou Y, Kruse AC, Chung KY, Kobilka TS, Thian FS, Chae PS, Pardon E, Calinski D, Mathiesen JM, Shah ST, Lyons JA, Caffrey M, Gellman SH, Steyaert J, Skiniotis G, Weis WI, Sunahara RK, Kobilka BK.
Nature
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Structural basis of specificity and cross-reactivity in T cell receptors specific for cytochrome c-I-E(k).
Authors: Authors: Newell EW, Ely LK, Kruse AC, Reay PA, Rodriguez SN, Lin AE, Kuhns MS, Garcia KC, Davis MM.
J Immunol
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Structure of a mutant ß toxin from Staphylococcus aureus reveals domain swapping and conformational flexibility.
Authors: Authors: Kruse AC, Huseby MJ, Shi K, Digre J, Ohlendorf DH, Earhart CA.
Acta Crystallogr Sect F Struct Biol Cryst Commun
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