Andrew Kruse, Ph.D.
Professor of Biological Chemistry and Molecular Pharmacology
Our research aims to elucidate the molecular basis of membrane protein signaling using techniques including protein engineering, structural biology, and pharmacology.
Research:
Signal transduction across cell membranes plays a central role in human physiology and disease, yet the mechanistic details underlying transmembrane signaling remain poorly understood. Our research aims to elucidate the molecular basis of membrane protein signaling using techniques including protein engineering, structural biology, and pharmacology. In particular, we are focused on the study of proteins important in human health and disease, including G protein-coupled receptors and other proteins that regulate neurotransmission and metabolic homeostasis.
G protein-coupled receptors (GPCRs) are cell-surface receptors that regulate neurotransmission, cardiovascular function, metabolic homeostasis, and many other physiological processes. Due to their central role in human physiology, these receptors are among the most important targets of therapeutic drugs, and are they among the most extensively studied proteins. To better understand GPCR signal transduction at a molecular level, we are using structural biology and biophysical methods to study model GPCRs such as muscarinic acetylcholine receptors. In addition, we are using new approaches in combinatorial biology to facilitate structural studies and to create protein ligands of GPCRs.
We are also interested in signal transduction pathways that remain less extensively studied than GPCRs, particularly receptors involved in the regulation of human metabolic homeostasis. In the long term, we hope to leverage our understanding of molecular signal transduction to guide the development of new and better therapeutics that modulate these pathways.
Address:
Room SGM - 227
250 Longwood Avenue
Boston, MA 02115
Publications View
Measurement of the centrality and pseudorapidity dependence of the integrated elliptic flow in lead-lead collisions at [Formula: see text] TeV with the ATLAS detector.
Authors: Authors: Aad G, Abbott B, Abdallah J, Abdel Khalek S, Abdinov O, Aben R, Abi B, Abolins M, AbouZeid OS, Abramowicz H, Abreu H, Abreu R, Abulaiti Y, Acharya BS, Adamczyk L, Adams DL, Adelman J, Adomeit S, Adye T, Agatonovic-Jovin T, Aguilar-Saavedra JA, Agustoni M, Ahlen SP, Ahmadov F, Aielli G, Åkesson TP, Akimoto G, Akimov AV, Alberghi GL, Albert J, Albrand S, Alconada Verzini MJ, Aleksa M, Aleksandrov IN, Alexa C, Alexander G, Alexandre G, Alexopoulos T, Alhroob M, Alimonti G, Alio L, Alison J, Allbrooke BM, Allison LJ, Allport PP, Allwood-Spiers SE, Almond J, Aloisio A, Alonso A, Alonso F, Alpigiani C, Altheimer A, Alvarez Gonzalez B, Alviggi MG, Amako K, Amaral Coutinho Y, Amelung C, Amidei D, Amor Dos Santos SP, Amorim A, Amoroso S, Amram N, Amundsen G, Anastopoulos C, Ancu LS, Andari N, Andeen T, Anders CF, Anders G, Anderson KJ, Andreazza A, Andrei V, Anduaga XS, Angelidakis S, Angelozzi I, Anger P, Angerami A, Anghinolfi F, Anisenkov AV, Anjos N, Annovi A, Antonaki A, Antonelli M, Antonov A, Antos J, Anulli F, Aoki M, Aperio Bella L, Apolle R, Arabidze G, Aracena I, Arai Y, Araque JP, Arce AT, Arguin JF, Argyropoulos S, Arik M, Armbruster AJ, Arnaez O, Arnal V, Arnold H, Arslan O, Artamonov A, Artoni G, Asai S, Asbah N, Ashkenazi A, Ask S, Åsman B, Asquith L, Assamagan K, Astalos R, Atkinson M, Atlay NB, Auerbach B, Augsten K, Aurousseau M, Avolio G, Azuelos G, Azuma Y, Baak MA, Bacci C, Bachacou H, Bachas K, Backes M, Backhaus M, Backus Mayes J, Badescu E, Bagiacchi P, Bagnaia P, Bai Y, Bain T, Baines JT, Baker OK, Baker S, Balek P, Balli F, Banas E, Banerjee S, Bangert A, Bannoura AA, Bansal V, Bansil HS, Barak L, Baranov SP, Barberio EL, Barberis D, Barbero M, Barillari T, Barisonzi M, Barklow T, Barlow N, Barnett BM, Barnett RM, Barnovska Z, Baroncelli A, Barone G, Barr AJ, Barreiro F, Barreiro Guimarães da Costa J, Bartoldus R, Barton AE, Bartos P, Bartsch V, Bassalat A, Basye A, Bates RL, Batkova L, Batley JR, Battistin M, Bauer F, Bawa HS, Beau T, Beauchemin PH, Beccherle R, Bechtle P, Beck HP, Becker K, Becker S, Beckingham M, Becot C, Beddall AJ, Beddall A, Bedikian S, Bednyakov VA, Bee CP, Beemster LJ, Beermann TA, Begel M, Behr K, Belanger-Champagne C, Bell PJ, Bell WH, Bella G, Bellagamba L, Bellerive A, Bellomo M, Belloni A, Belotskiy K, Beltramello O, Benary O, Benchekroun D, Bendtz K, Benekos N, Benhammou Y, Benhar Noccioli E, Benitez Garcia JA, Benjamin DP, Bensinger JR, Benslama K, Bentvelsen S, Berge D, Bergeaas Kuutmann E, Berger N, Berghaus F, Berglund E, Beringer J, Bernard C, Bernat P, Bernius C, Bernlochner FU, Berry T, Berta P, Bertella C, Bertolucci F, Besana MI, Besjes GJ, Bessidskaia O, Besson N, Betancourt C, Bethke S, Bhimji W, Bianchi RM, Bianchini L, Bianco M, Biebel O, Bieniek SP, Bierwagen K, Biesiada J, Biglietti M, Bilbao De Mendizabal J, Bilokon H, Bindi M, Binet S, Bingul A, Bini C, Black CW, Black JE, Black KM, Blackburn D, Blair RE, Blanchard JB, Blazek T, Bloch I, Blocker C, Blum W, Blumenschein U, Bobbink GJ, Bobrovnikov VS, Bocchetta SS, Bocci A, Boddy CR, Boehler M, Boek J, Boek TT, Bogaerts JA, Bogdanchikov AG, Bogouch A, Bohm C, Bohm J, Boisvert V, Bold T, Boldea V, Boldyrev AS, Bomben M, Bona M, Boonekamp M, Borisov A, Borissov G, Borri M, Borroni S, Bortfeldt J, Bortolotto V, Bos K, Boscherini D, Bosman M, Boterenbrood H, Boudreau J, Bouffard J, Bouhova-Thacker EV, Boumediene D, Bourdarios C, Bousson N, Boutouil S, Boveia A, Boyd J, Boyko IR, Bozovic-Jelisavcic I, Bracinik J, Branchini P, Brandt A, Brandt G, Brandt O, Bratzler U, Brau B, Brau JE, Braun HM, Brazzale SF, Brelier B, Brendlinger K, Brennan AJ, Brenner R, Bressler S, Bristow K, Bristow TM, Britton D, Brochu FM, Brock I, Brock R, Bromberg C, Bronner J, Brooijmans G, Brooks T, Brooks WK, Brosamer J, Brost E, Brown G, Brown J, Bruckman de Renstrom PA, Bruncko D, Bruneliere R, Brunet S, Bruni A, Bruni G, Bruschi M, Bryngemark L, Buanes T, Buat Q, Bucci F, Buchholz P, Buckingham RM, Buckley AG, Buda SI, Budagov IA, et al.
Eur Phys J C Part Fields
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Eur Phys J C Part Fields
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Measurement of the muon reconstruction performance of the ATLAS detector using 2011 and 2012 LHC proton-proton collision data.
Authors: Authors: Aad G, Abbott B, Abdallah J, Abdel Khalek S, Abdinov O, Aben R, Abi B, Abolins M, AbouZeid OS, Abramowicz H, Abreu H, Abreu R, Abulaiti Y, Acharya BS, Adamczyk L, Adams DL, Adelman J, Adomeit S, Adye T, Agatonovic-Jovin T, Aguilar-Saavedra JA, Agustoni M, Ahlen SP, Ahmadov F, Aielli G, Akerstedt H, Åkesson TP, Akimoto G, Akimov AV, Alberghi GL, Albert J, Albrand S, Alconada Verzini MJ, Aleksa M, Aleksandrov IN, Alexa C, Alexander G, Alexandre G, Alexopoulos T, Alhroob M, Alimonti G, Alio L, Alison J, Allbrooke BM, Allison LJ, Allport PP, Almond J, Aloisio A, Alonso A, Alonso F, Alpigiani C, Altheimer A, Alvarez Gonzalez B, Alviggi MG, Amako K, Amaral Coutinho Y, Amelung C, Amidei D, Amor Dos Santos SP, Amorim A, Amoroso S, Amram N, Amundsen G, Anastopoulos C, Ancu LS, Andari N, Andeen T, Anders CF, Anders G, Anderson KJ, Andreazza A, Andrei V, Anduaga XS, Angelidakis S, Angelozzi I, Anger P, Angerami A, Anghinolfi F, Anisenkov AV, Anjos N, Annovi A, Antonaki A, Antonelli M, Antonov A, Antos J, Anulli F, Aoki M, Aperio Bella L, Apolle R, Arabidze G, Aracena I, Arai Y, Araque JP, Arce AT, Arguin JF, Argyropoulos S, Arik M, Armbruster AJ, Arnaez O, Arnal V, Arnold H, Arratia M, Arslan O, Artamonov A, Artoni G, Asai S, Asbah N, Ashkenazi A, Åsman B, Asquith L, Assamagan K, Astalos R, Atkinson M, Atlay NB, Auerbach B, Augsten K, Aurousseau M, Avolio G, Azuelos G, Azuma Y, Baak MA, Baas A, Bacci C, Bachacou H, Bachas K, Backes M, Backhaus M, Backus Mayes J, Badescu E, Bagiacchi P, Bagnaia P, Bai Y, Bain T, Baines JT, Baker OK, Balek P, Balli F, Banas E, Banerjee S, Bannoura AA, Bansal V, Bansil HS, Barak L, Baranov SP, Barberio EL, Barberis D, Barbero M, Barillari T, Barisonzi M, Barklow T, Barlow N, Barnett BM, Barnett RM, Barnovska Z, Baroncelli A, Barone G, Barr AJ, Barreiro F, Barreiro Guimarães da Costa J, Bartoldus R, Barton AE, Bartos P, Bartsch V, Bassalat A, Basye A, Bates RL, Batley JR, Battaglia M, Battistin M, Bauer F, Bawa HS, Beattie MD, Beau T, Beauchemin PH, Beccherle R, Bechtle P, Beck HP, Becker K, Becker S, Beckingham M, Becot C, Beddall AJ, Beddall A, Bedikian S, Bednyakov VA, Bee CP, Beemster LJ, Beermann TA, Begel M, Behr K, Belanger-Champagne C, Bell PJ, Bell WH, Bella G, Bellagamba L, Bellerive A, Bellomo M, Belotskiy K, Beltramello O, Benary O, Benchekroun D, Bendtz K, Benekos N, Benhammou Y, Benhar Noccioli E, Benitez Garcia JA, Benjamin DP, Bensinger JR, Benslama K, Bentvelsen S, Berge D, Bergeaas Kuutmann E, Berger N, Berghaus F, Beringer J, Bernard C, Bernat P, Bernius C, Bernlochner FU, Berry T, Berta P, Bertella C, Bertoli G, Bertolucci F, Bertsche C, Bertsche D, Bessner M, Besana MI, Besjes GJ, Bessidskaia O, Besson N, Betancourt C, Bethke S, Bhimji W, Bianchi RM, Bianchini L, Bianco M, Biebel O, Bieniek SP, Bierwagen K, Biesiada J, Biglietti M, Bilbao De Mendizabal J, Bilokon H, Bindi M, Binet S, Bingul A, Bini C, Black CW, Black JE, Black KM, Blackburn D, Blair RE, Blanchard JB, Blazek T, Bloch I, Blocker C, Blum W, Blumenschein U, Bobbink GJ, Bobrovnikov VS, Bocchetta SS, Bocci A, Bock C, Boddy CR, Boehler M, Boek TT, Bogaerts JA, Bogdanchikov AG, Bogouch A, Bohm C, Bohm J, Boisvert V, Bold T, Boldea V, Boldyrev AS, Bomben M, Bona M, Boonekamp M, Borisov A, Borissov G, Borri M, Borroni S, Bortfeldt J, Bortolotto V, Bos K, Boscherini D, Bosman M, Boterenbrood H, Boudreau J, Bouffard J, Bouhova-Thacker EV, Boumediene D, Bourdarios C, Bousson N, Boutouil S, Boveia A, Boyd J, Boyko IR, Bracinik J, Brandt A, Brandt G, Brandt O, Bratzler U, Brau B, Brau JE, Braun HM, Brazzale SF, Brelier B, Brendlinger K, Brennan AJ, Brenner R, Bressler S, Bristow K, Bristow TM, Britton D, Brochu FM, Brock I, Brock R, Bromberg C, Bronner J, Brooijmans G, Brooks T, Brooks WK, Brosamer J, Brost E, Brown J, Bruckman de Renstrom PA, Bruncko D, Bruneliere R, Brunet S, Bruni A, Bruni G, Bruschi M, Bryngemark L, Buanes T, Buat Q, Bucci F, Buchholz P, Buckingham RM, Buckley AG, Buda SI, Budagov IA, Buehrer F, Bugge L, et al.
Eur Phys J C Part Fields
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Eur Phys J C Part Fields
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Electron reconstruction and identification efficiency measurements with the ATLAS detector using the 2011 LHC proton-proton collision data.
Authors: Authors: Aad G, Abajyan T, Abbott B, Abdallah J, Khalek SA, Abdinov O, Aben R, Abi B, Abolins M, AbouZeid OS, Abramowicz H, Abreu H, Abulaiti Y, Acharya BS, Adamczyk L, Adams DL, Addy TN, Adelman J, Adomeit S, Adye T, Agatonovic-Jovin T, Aguilar-Saavedra JA, Agustoni M, Ahlen SP, Ahmad A, Ahmadov F, Aielli G, Åkesson TP, Akimoto G, Akimov AV, Albert J, Albrand S, Verzini MJ, Aleksa M, Aleksandrov IN, Alexa C, Alexander G, Alexandre G, Alexopoulos T, Alhroob M, Alimonti G, Alio L, Alison J, Allbrooke BM, Allison LJ, Allport PP, Allwood-Spiers SE, Almond J, Aloisio A, Alon R, Alonso A, Alonso F, Alpigiani C, Altheimer A, Gonzalez BA, Alviggi MG, Amako K, Coutinho YA, Amelung C, Amidei D, Ammosov VV, Santos SP, Amorim A, Amoroso S, Amram N, Amundsen G, Anastopoulos C, Ancu LS, Andari N, Andeen T, Anders CF, Anders G, Anderson KJ, Andreazza A, Andrei V, Anduaga XS, Angelidakis S, Anger P, Angerami A, Anghinolfi F, Anisenkov AV, Anjos N, Annovi A, Antonaki A, Antonelli M, Antonov A, Antos J, Anulli F, Aoki M, Bella LA, Apolle R, Arabidze G, Aracena I, Arai Y, Araque JP, Arce AT, Arguin JF, Argyropoulos S, Arik M, Armbruster AJ, Arnaez O, Arnal V, Arslan O, Artamonov A, Artoni G, Asai S, Asbah N, Ashkenazi A, Ask S, Åsman B, Asquith L, Assamagan K, Astalos R, Atkinson M, Atlay NB, Auerbach B, Auge E, Augsten K, Aurousseau M, Avolio G, Azuelos G, Azuma Y, Baak MA, Bacci C, Bach AM, Bachacou H, Bachas K, Backes M, Backhaus M, Mayes JB, Badescu E, Bagiacchi P, Bagnaia P, Bai Y, Bailey DC, Bain T, Baines JT, Baker OK, Baker S, Balek P, Balli F, Banas E, Banerjee S, Banfi D, Bangert A, Bannoura AA, Bansal V, Bansil HS, Barak L, Baranov SP, Barber T, Barberio EL, Barberis D, Barbero M, Barillari T, Barisonzi M, Barklow T, Barlow N, Barnett BM, Barnett RM, Barnovska Z, Baroncelli A, Barone G, Barr AJ, Barreiro F, Costa JB, Bartoldus R, Barton AE, Bartos P, Bartsch V, Bassalat A, Basye A, Bates RL, Batkova L, Batley JR, Battistin M, Bauer F, Bawa HS, Beau T, Beauchemin PH, Beccherle R, Bechtle P, Beck HP, Becker K, Becker S, Beckingham M, Becot C, Beddall AJ, Beddall A, Bedikian S, Bednyakov VA, Bee CP, Beemster LJ, Beermann TA, Begel M, Behr K, Belanger-Champagne C, Bell PJ, Bell WH, Bella G, Bellagamba L, Bellerive A, Bellomo M, Belloni A, Belotskiy K, Beltramello O, Benary O, Benchekroun D, Bendtz K, Benekos N, Benhammou Y, Noccioli EB, Garcia JA, Benjamin DP, Bensinger JR, Benslama K, Bentvelsen S, Berge D, Kuutmann EB, Berger N, Berghaus F, Berglund E, Beringer J, Bernard C, Bernat P, Bernius C, Bernlochner FU, Berry T, Berta P, Bertella C, Bertolucci F, Besana MI, Besjes GJ, Bessidskaia O, Besson N, Betancourt C, Bethke S, Bhimji W, Bianchi RM, Bianchini L, Bianco M, Biebel O, Bieniek SP, Bierwagen K, Biesiada J, Biglietti M, De Mendizabal JB, Bilokon H, Bindi M, Binet S, Bingul A, Bini C, Black CW, Black JE, Black KM, Blackburn D, Blair RE, Blanchard JB, Blazek T, Bloch I, Blocker C, Blum W, Blumenschein U, Bobbink GJ, Bobrovnikov VS, Bocchetta SS, Bocci A, Boddy CR, Boehler M, Boek J, Boek TT, Bogaerts JA, Bogdanchikov AG, Bogouch A, Bohm C, Bohm J, Boisvert V, Bold T, Boldea V, Boldyrev AS, Bolnet NM, Bomben M, Bona M, Boonekamp M, Borisov A, Borissov G, Borri M, Borroni S, Bortfeldt J, Bortolotto V, Bos K, Boscherini D, Bosman M, Boterenbrood H, Boudreau J, Bouffard J, Bouhova-Thacker EV, Boumediene D, Bourdarios C, Bousson N, Boutouil S, Boveia A, Boyd J, Boyko IR, Bozovic-Jelisavcic I, Bracinik J, Branchini P, Brandt A, Brandt G, Brandt O, Bratzler U, Brau B, Brau JE, Braun HM, Brazzale SF, Brelier B, Brendlinger K, Brennan AJ, Brenner R, Bressler S, Bristow K, Bristow TM, Britton D, Brochu FM, Brock I, Brock R, Bromberg C, Bronner J, Brooijmans G, Brooks T, Brooks WK, Brosamer J, Brost E, Brown G, Brown J, Renstrom PA, Bruncko D, Bruneliere R, Brunet S, Bruni A, Bruni G, Bruschi M, Bryngemark L, Buanes T, Buat Q, Bucci F, Buchholz P, Buckingham RM, Buckley AG, Buda SI, Budagov IA, Buehrer F, Bugge L, Bugge MK, Bulekov O, et al.
Eur Phys J C Part Fields
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Eur Phys J C Part Fields
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Activation and allosteric modulation of a muscarinic acetylcholine receptor.
Authors: Authors: Kruse AC, Ring AM, Manglik A, Hu J, Hu K, Eitel K, Hübner H, Pardon E, Valant C, Sexton PM, Christopoulos A, Felder CC, Gmeiner P, Steyaert J, Weis WI, Garcia KC, Wess J, Kobilka BK.
Nature
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Nature
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Novel tripod amphiphiles for membrane protein analysis.
Authors: Authors: Chae PS, Kruse AC, Gotfryd K, Rana RR, Cho KH, Rasmussen SG, Bae HE, Chandra R, Gether U, Guan L, Kobilka BK, Loland CJ, Byrne B, Gellman SH.
Chemistry
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Chemistry
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Applications of molecular replacement to G protein-coupled receptors.
Authors: Authors: Kruse AC, Manglik A, Kobilka BK, Weis WI.
Acta Crystallogr D Biol Crystallogr
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Acta Crystallogr D Biol Crystallogr
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Adrenaline-activated structure of ß2-adrenoceptor stabilized by an engineered nanobody.
Authors: Authors: Ring AM, Manglik A, Kruse AC, Enos MD, Weis WI, Garcia KC, Kobilka BK.
Nature
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Nature
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Muscarinic receptors as model targets and antitargets for structure-based ligand discovery.
Authors: Authors: Kruse AC, Weiss DR, Rossi M, Hu J, Hu K, Eitel K, Gmeiner P, Wess J, Kobilka BK, Shoichet BK.
Mol Pharmacol
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Mol Pharmacol
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Structure of active ß-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide.
Authors: Authors: Shukla AK, Manglik A, Kruse AC, Xiao K, Reis RI, Tseng WC, Staus DP, Hilger D, Uysal S, Huang LY, Paduch M, Tripathi-Shukla P, Koide A, Koide S, Weis WI, Kossiakoff AA, Kobilka BK, Lefkowitz RJ.
Nature
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Nature
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Glucose-neopentyl glycol (GNG) amphiphiles for membrane protein study.
Authors: Authors: Chae PS, Rana RR, Gotfryd K, Rasmussen SG, Kruse AC, Cho KH, Capaldi S, Carlsson E, Kobilka B, Loland CJ, Gether U, Banerjee S, Byrne B, Lee JK, Gellman SH.
Chem Commun (Camb)
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Chem Commun (Camb)
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