Piotr Sliz

Piotr Sliz, Ph.D.

Associate Professor of Pediatrics
Associate Professor of Biological Chemistry and Molecular Pharmacology

Our primary research interest is to understand the molecular details of specialized, noncanonical mechanisms that regulate gene expression.

Research:

Our primary research interest is to understand the molecular details of specialized, noncanonical mechanisms that regulate gene expression. Various proteins have evolved to act as specific modulators of genes in order to fine-tune their activity as well as to quickly respond to environmental cues. We focus on investigating the regulators that are directly involved in major human diseases such as cancer and diabetes. By employing biochemical and structural approaches, we not only aim to understand the molecular mechanism, but also to use the details provided by high-resolution structures for identifying potential therapeutic avenues. For appropriate candidate macromolecules we utilize computational techniques such as molecular dynamics and in silico docking to design small molecule inhibitors and to understand their interactions.

Address: 

C Building, Room 215

240 Longwood Avenue

Boston, MA 02115

Publications View
Aquaporin-0 membrane junctions reveal the structure of a closed water pore.
Authors: Authors: Gonen T, Sliz P, Kistler J, Cheng Y, Walz T.
Nature
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An asymmetric NFAT1 dimer on a pseudo-palindromic kappa B-like DNA site.
Authors: Authors: Jin L, Sliz P, Chen L, Macián F, Rao A, Hogan PG, Harrison SC.
Nat Struct Biol
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How does radiation damage in protein crystals depend on X-ray dose?
Authors: Authors: Sliz P, Harrison SC, Rosenbaum G.
Structure
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Crystal structures of two closely related but antigenically distinct HLA-A2/melanocyte-melanoma tumor-antigen peptide complexes.
Authors: Authors: Sliz P, Michielin O, Cerottini JC, Luescher I, Romero P, Karplus M, Wiley DC.
J Immunol
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The structure of enzyme IIAlactose from Lactococcus lactis reveals a new fold and points to possible interactions of a multicomponent system.
Authors: Authors: Sliz P, Engelmann R, Hengstenberg W, Pai EF.
Structure
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Crystallization and preliminary structural studies of lactose-specific enzyme IIA from Lactococcus lactis.
Authors: Authors: Sliz P, Schörter KH, De Vos WM, Pai EF.
Acta Crystallogr D Biol Crystallogr
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Structure, Function and Interactions of Enzyme IIA from the Phosphoenolpyruvate:lactose Phosphotransferase
Authors: Authors: Piotr Sliz
2000.