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Loren David Walensky, M.D., Ph.D.

Professor of Pediatrics
617-355-6369
Publications View
Direct and selective small-molecule activation of proapoptotic BAX.
Authors: Authors: Gavathiotis E, Reyna DE, Bellairs JA, Leshchiner ES, Walensky LD.
Nat Chem Biol
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Stemming danger with Golgified BAX.
Authors: Authors: Walensky LD.
Mol Cell
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A stapled BIM peptide overcomes apoptotic resistance in hematologic cancers.
Authors: Authors: LaBelle JL, Katz SG, Bird GH, Gavathiotis E, Stewart ML, Lawrence C, Fisher JK, Godes M, Pitter K, Kung AL, Walensky LD.
J Clin Invest
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From mitochondrial biology to magic bullet: navitoclax disarms BCL-2 in chronic lymphocytic leukemia.
Authors: Authors: Walensky LD.
J Clin Oncol
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BAX unleashed: the biochemical transformation of an inactive cytosolic monomer into a toxic mitochondrial pore.
Authors: Authors: Walensky LD, Gavathiotis E.
Trends Biochem Sci
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Chemical synthesis of hydrocarbon-stapled peptides for protein interaction research and therapeutic targeting.
Authors: Authors: Bird GH, Crannell WC, Walensky LD.
Curr Protoc Chem Biol
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Tracking BAX once its trigger is pulled.
Authors: Authors: Gavathiotis E, Walensky LD.
Cell Cycle
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Characterization of a core fragment of the rhesus monkey TRIM5a protein.
Authors: Authors: Kar AK, Mao Y, Bird G, Walensky L, Sodroski J.
BMC Biochem
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Photoreactive stapled BH3 peptides to dissect the BCL-2 family interactome.
Authors: Authors: Braun CR, Mintseris J, Gavathiotis E, Bird GH, Gygi SP, Walensky LD.
Chem Biol
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A stapled p53 helix overcomes HDMX-mediated suppression of p53.
Authors: Authors: Bernal F, Wade M, Godes M, Davis TN, Whitehead DG, Kung AL, Wahl GM, Walensky LD.
Cancer Cell
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