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Shamil R. Sunyaev, Ph.D.

Professor of Medicine
617-525-6675
Publications View
Estimating the selective effects of heterozygous protein-truncating variants from human exome data.
Authors: Authors: Cassa CA, Weghorn D, Balick DJ, Jordan DM, Nusinow D, Samocha KE, O'Donnell-Luria A, MacArthur DG, Daly MJ, Beier DR, Sunyaev SR.
Nat Genet
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Limited statistical evidence for shared genetic effects of eQTLs and autoimmune-disease-associated loci in three major immune-cell types.
Authors: Authors: Chun S, Casparino A, Patsopoulos NA, Croteau-Chonka DC, Raby BA, De Jager PL, Sunyaev SR, Cotsapas C.
Nat Genet
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Variants in angiopoietin-2 (ANGPT2) contribute to variation in nocturnal oxyhaemoglobin saturation level.
Authors: Authors: Wang H, Cade BE, Chen H, Gleason KJ, Saxena R, Feng T, Larkin EK, Vasan RS, Lin H, Patel SR, Tracy RP, Liu Y, Gottlieb DJ, Below JE, Hanis CL, Petty LE, Sunyaev SR, Frazier-Wood AC, Rotter JI, Post W, Lin X, Redline S, Zhu X.
Hum Mol Genet
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Quantifying unobserved protein-coding variants in human populations provides a roadmap for large-scale sequencing projects.
Authors: Authors: Zou J, Valiant G, Valiant P, Karczewski K, Chan SO, Samocha K, Lek M, Sunyaev S, Daly M, MacArthur DG.
Nat Commun
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Increasing Generality and Power of Rare-Variant Tests by Utilizing Extended Pedigrees.
Authors: Authors: Sul JH, Cade BE, Cho MH, Qiao D, Silverman EK, Redline S, Sunyaev S.
Am J Hum Genet
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Genetic Associations with Obstructive Sleep Apnea Traits in Hispanic/Latino Americans.
Authors: Authors: Cade BE, Chen H, Stilp AM, Gleason KJ, Sofer T, Ancoli-Israel S, Arens R, Bell GI, Below JE, Bjonnes AC, Chun S, Conomos MP, Evans DS, Johnson WC, Frazier-Wood AC, Lane JM, Larkin EK, Loredo JS, Post WS, Ramos AR, Rice K, Rotter JI, Shah NA, Stone KL, Taylor KD, Thornton TA, Tranah GJ, Wang C, Zee PC, Hanis CL, Sunyaev SR, Patel SR, Laurie CC, Zhu X, Saxena R, Lin X, Redline S.
Am J Respir Crit Care Med
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Excess of Deleterious Mutations around HLA Genes Reveals Evolutionary Cost of Balancing Selection.
Authors: Authors: Lenz TL, Spirin V, Jordan DM, Sunyaev SR.
Mol Biol Evol
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Pathogenicity Interpretation in the Age of Precision Medicine: The 2015 Annual Scientific Meeting of the Human Genome Variation Society.
Authors: Authors: Oetting WS, Brenner SE, Brookes AJ, Greenblatt MS, Hart RK, Karchin R, Sunyaev SR, Taschner PE.
Hum Mutat
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An argument for early genomic sequencing in atypical cases: a WISP3 variant leads to diagnosis of progressive pseudorheumatoid arthropathy of childhood.
Authors: Authors: Cassa CA, Smith SE, Docken W, Hoffman E, McLaughlin H, Chun S, Leshchiner I, Miraoui H, Raychaudhuri S, Frank NY, Wilson BJ, Sunyaev SR, Maas RL, Vuzman D.
Rheumatology (Oxford)
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Genes with monoallelic expression contribute disproportionately to genetic diversity in humans.
Authors: Authors: Savova V, Chun S, Sohail M, McCole RB, Witwicki R, Gai L, Lenz TL, Wu CT, Sunyaev SR, Gimelbrant AA.
Nat Genet
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