Publications View
G protein-coupled receptors (GPCRs) That Signal via Protein Kinase A (PKA) Cross-talk at Insulin Receptor Substrate 1 (IRS1) to Activate the phosphatidylinositol 3-kinase (PI3K)/AKT Pathway.
IRS proteins and diabetic complications.
Insulin receptor substrate-1 deficiency drives a proinflammatory phenotype in KRAS mutant lung adenocarcinoma.
Authors: Authors: Metz HE, Kargl J, Busch SE, Kim KH, Kurland BF, Abberbock SR, Randolph-Habecker J, Knoblaugh SE, Kolls JK, White MF, Houghton AM.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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Serine 302 Phosphorylation of Mouse Insulin Receptor Substrate 1 (IRS1) Is Dispensable for Normal Insulin Signaling and Feedback Regulation by Hepatic S6 Kinase.
Trimeprazine increases IRS2 in human islets and promotes pancreatic ß cell growth and function in mice.
Authors: Authors: Kuznetsova A, Yu Y, Hollister-Lock J, Opare-Addo L, Rozzo A, Sadagurski M, Norquay L, Reed JE, El Khattabi I, Bonner-Weir S, Weir GC, Sharma A, White MF.
JCI Insight
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JCI Insight
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Longevity: Mapping the path to a longer life.
Insulin receptor substrates are essential for the bioenergetic and hypertrophic response of the heart to exercise training.
Authors: Authors: Riehle C, Wende AR, Zhu Y, Oliveira KJ, Pereira RO, Jaishy BP, Bevins J, Valdez S, Noh J, Kim BJ, Moreira AB, Weatherford ET, Manivel R, Rawlings TA, Rech M, White MF, Abel ED.
Mol Cell Biol
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Mol Cell Biol
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APPL1 potentiates insulin sensitivity by facilitating the binding of IRS1/2 to the insulin receptor.
Authors: Authors: Ryu J, Galan AK, Xin X, Dong F, Abdul-Ghani MA, Zhou L, Wang C, Li C, Holmes BM, Sloane LB, Austad SN, Guo S, Musi N, DeFronzo RA, Deng C, White MF, Liu F, Dong LQ.
Cell Rep
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Cell Rep
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Insulin and metabolic stress stimulate multisite serine/threonine phosphorylation of insulin receptor substrate 1 and inhibit tyrosine phosphorylation.
Authors: Authors: Hançer NJ, Qiu W, Cherella C, Li Y, Copps KD, White MF.
J Biol Chem
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J Biol Chem
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Irs2 and Irs4 synergize in non-LepRb neurons to control energy balance and glucose homeostasis.