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Anthony George Letai, M.D., Ph.D.

Professor of Medicine
617-632-2348
Publications View
Overcoming mutational complexity in acute myeloid leukemia by inhibition of critical pathways.
Authors: Authors: Saito Y, Mochizuki Y, Ogahara I, Watanabe T, Hogdal L, Takagi S, Sato K, Kaneko A, Kajita H, Uchida N, Fukami T, Shultz LD, Taniguchi S, Ohara O, Letai AG, Ishikawa F.
Sci Transl Med
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BCL-XL directly modulates RAS signalling to favour cancer cell stemness.
Authors: Authors: Carné Trécesson S, Souazé F, Basseville A, Bernard AC, Pécot J, Lopez J, Bessou M, Sarosiek KA, Letai A, Barillé-Nion S, Valo I, Coqueret O, Guette C, Campone M, Gautier F, Juin PP.
Nat Commun
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Bruton's tyrosine kinase inhibition increases BCL-2 dependence and enhances sensitivity to venetoclax in chronic lymphocytic leukemia.
Authors: Authors: Deng J, Isik E, Fernandes SM, Brown JR, Letai A, Davids MS.
Leukemia
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Functional precision cancer medicine-moving beyond pure genomics.
Authors: Authors: Letai A.
Nat Med
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Epistatic mutations in PUMA BH3 drive an alternate binding mode to potently and selectively inhibit anti-apoptotic Bfl-1.
Authors: Authors: Jenson JM, Ryan JA, Grant RA, Letai A, Keating AE.
Elife
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Synergistic interactions with PI3K inhibition that induce apoptosis.
Authors: Authors: Zwang Y, Jonas O, Chen C, Rinne ML, Doench JG, Piccioni F, Tan L, Huang HT, Wang J, Ham YJ, O'Connell J, Bhola P, Doshi M, Whitman M, Cima M, Letai A, Root DE, Langer RS, Gray N, Hahn WC.
Elife
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Epstein-Barr virus ensures B cell survival by uniquely modulating apoptosis at early and late times after infection.
Authors: Authors: Price AM, Dai J, Bazot Q, Patel L, Nikitin PA, Djavadian R, Winter PS, Salinas CA, Barry AP, Wood KC, Johannsen EC, Letai A, Allday MJ, Luftig MA.
Elife
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Class IIa HDAC inhibition reduces breast tumours and metastases through anti-tumour macrophages.
Authors: Authors: Guerriero JL, Sotayo A, Ponichtera HE, Castrillon JA, Pourzia AL, Schad S, Johnson SF, Carrasco RD, Lazo S, Bronson RT, Davis SP, Lobera M, Nolan MA, Letai A.
Nature
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Complementary dynamic BH3 profiles predict co-operativity between the multi-kinase inhibitor TG02 and the BH3 mimetic ABT-199 in acute myeloid leukaemia cells.
Authors: Authors: Pallis M, Burrows F, Ryan J, Grundy M, Seedhouse C, Abdul-Aziz A, Montero J, Letai A, Russell N.
Oncotarget
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Blastic Plasmacytoid Dendritic Cell Neoplasm Is Dependent on BCL2 and Sensitive to Venetoclax.
Authors: Authors: Montero J, Stephansky J, Cai T, Griffin GK, Cabal-Hierro L, Togami K, Hogdal LJ, Galinsky I, Morgan EA, Aster JC, Davids MS, LeBoeuf NR, Stone RM, Konopleva M, Pemmaraju N, Letai A, Lane AA.
Cancer Discov
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