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Loren David Walensky, M.D., Ph.D.

Professor of Pediatrics
617-355-6369
Publications View
Direct Activation of BAX by BTSA1 Overcomes Apoptosis Resistance in Acute Myeloid Leukemia.
Authors: Authors: Reyna DE, Garner TP, Lopez A, Kopp F, Choudhary GS, Sridharan A, Narayanagari SR, Mitchell K, Dong B, Bartholdy BA, Walensky LD, Verma A, Steidl U, Gavathiotis E.
Cancer Cell
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Extra-mitochondrial prosurvival BCL-2 proteins regulate gene transcription by inhibiting the SUFU tumour suppressor.
Authors: Authors: Wu X, Zhang LS, Toombs J, Kuo YC, Piazza JT, Tuladhar R, Barrett Q, Fan CW, Zhang X, Walensky LD, Kool M, Cheng SY, Brekken R, Opferman JT, Green DR, Moldoveanu T, Lum L.
Nat Cell Biol
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Allosteric sensitization of proapoptotic BAX.
Authors: Authors: Pritz JR, Wachter F, Lee S, Luccarelli J, Wales TE, Cohen DT, Coote P, Heffron GJ, Engen JR, Massefski W, Walensky LD.
Nat Chem Biol
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Bim gene dosage is critical in modulating nephron progenitor survival in the absence of microRNAs during kidney development.
Authors: Authors: Cerqueira DM, Bodnar AJ, Phua YL, Freer R, Hemker SL, Walensky LD, Hukriede NA, Ho J.
FASEB J
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Mechanistic validation of a clinical lead stapled peptide that reactivates p53 by dual HDM2 and HDMX targeting.
Authors: Authors: Wachter F, Morgan AM, Godes M, Mourtada R, Bird GH, Walensky LD.
Oncogene
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Challenges in Targeting a Basic Helix-Loop-Helix Transcription Factor with Hydrocarbon-Stapled Peptides.
Authors: Authors: Edwards AL, Meijer DH, Guerra RM, Molenaar RJ, Alberta JA, Bernal F, Bird GH, Stiles CD, Walensky LD.
ACS Chem Biol
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Biophysical determinants for cellular uptake of hydrocarbon-stapled peptide helices.
Authors: Authors: Bird GH, Mazzola E, Opoku-Nsiah K, Lammert MA, Godes M, Neuberg DS, Walensky LD.
Nat Chem Biol
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Selective Covalent Targeting of Anti-Apoptotic BFL-1 by Cysteine-Reactive Stapled Peptide Inhibitors.
Authors: Authors: Huhn AJ, Guerra RM, Harvey EP, Bird GH, Walensky LD.
Cell Chem Biol
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Allosteric inhibition of antiapoptotic MCL-1.
Authors: Authors: Lee S, Wales TE, Escudero S, Cohen DT, Luccarelli J, Gallagher CG, Cohen NA, Huhn AJ, Bird GH, Engen JR, Walensky LD.
Nat Struct Mol Biol
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Reply to Fernandez-Marrero et al.: Role of BOK at the intersection of endoplasmic reticulum stress and apoptosis regulation.
Authors: Authors: Carpio MA, Michaud M, Zhou W, Fisher JK, Walensky LD, Katz SG.
Proc Natl Acad Sci U S A
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