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Loren David Walensky, M.D., Ph.D.

Professor of Pediatrics
617-355-6369
Publications View
SWI/SNF-mutant cancers depend on catalytic and non-catalytic activity of EZH2.
Authors: Authors: Kim KH, Kim W, Howard TP, Vazquez F, Tsherniak A, Wu JN, Wang W, Haswell JR, Walensky LD, Hahn WC, Orkin SH, Roberts CW.
Nat Med
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Generation of multiple reporter ions from a single isobaric reagent increases multiplexing capacity for quantitative proteomics.
Authors: Authors: Braun CR, Bird GH, Wühr M, Erickson BK, Rad R, Walensky LD, Gygi SP, Haas W.
Anal Chem
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Cellular Uptake and Ultrastructural Localization Underlie the Pro-apoptotic Activity of a Hydrocarbon-stapled BIM BH3 Peptide.
Authors: Authors: Edwards AL, Wachter F, Lammert M, Huhn AJ, Luccarelli J, Bird GH, Walensky LD.
ACS Chem Biol
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Regulation of mitochondrial ceramide distribution by members of the BCL-2 family.
Authors: Authors: Zhang T, Barclay L, Walensky LD, Saghatelian A.
J Lipid Res
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A nonapoptotic role for BAX and BAK in eicosanoid metabolism.
Authors: Authors: Zhang T, Walensky LD, Saghatelian A.
ACS Chem Biol
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BCL-2 family member BOK promotes apoptosis in response to endoplasmic reticulum stress.
Authors: Authors: Carpio MA, Michaud M, Zhou W, Fisher JK, Walensky LD, Katz SG.
Proc Natl Acad Sci U S A
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Inhibition of Pro-apoptotic BAX by a noncanonical interaction mechanism.
Authors: Authors: Barclay LA, Wales TE, Garner TP, Wachter F, Lee S, Guerra RM, Stewart ML, Braun CR, Bird GH, Gavathiotis E, Engen JR, Walensky LD.
Mol Cell
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Direct inhibition of oncogenic KRAS by hydrocarbon-stapled SOS1 helices.
Authors: Authors: Leshchiner ES, Parkhitko A, Bird GH, Luccarelli J, Bellairs JA, Escudero S, Opoku-Nsiah K, Godes M, Perrimon N, Walensky LD.
Proc Natl Acad Sci U S A
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Phospho-BAD BH3 mimicry protects ß cells and restores functional ß cell mass in diabetes.
Authors: Authors: Ljubicic S, Polak K, Fu A, Wiwczar J, Szlyk B, Chang Y, Alvarez-Perez JC, Bird GH, Walensky LD, Garcia-Ocaña A, Danial NN.
Cell Rep
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Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma.
Authors: Authors: Perry JA, Kiezun A, Tonzi P, Van Allen EM, Carter SL, Baca SC, Cowley GS, Bhatt AS, Rheinbay E, Pedamallu CS, Helman E, Taylor-Weiner A, McKenna A, DeLuca DS, Lawrence MS, Ambrogio L, Sougnez C, Sivachenko A, Walensky LD, Wagle N, Mora J, de Torres C, Lavarino C, Dos Santos Aguiar S, Yunes JA, Brandalise SR, Mercado-Celis GE, Melendez-Zajgla J, Cárdenas-Cardós R, Velasco-Hidalgo L, Roberts CW, Garraway LA, Rodriguez-Galindo C, Gabriel SB, Lander ES, Golub TR, Orkin SH, Getz G, Janeway KA.
Proc Natl Acad Sci U S A
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