Professor of Medicine and Biological Chemistry and Molecular Pharmacology
Our research involves the chemical biology of protein post-translational modifcations (PTMs) in the context of signaling, epigenetics, and cancer. We develop and apply chemical approaches including protein semisynthesis and small molecule probes to the study of protein phosphorylation, acetylation, ubiquitination, and other PTMs in enzymes and cellular networks.
Dean of the Faculty of Medicine, Professor of Biological Chemistry and Molecular Pharmacology
The laboratory focuses on stem cell biology, with an emphasis on hematopoietic differentiation from human and mouse pluripotent stem cells (embryonic stem, ES, and induced Pluirpotent Stem, iPS) cells, epigenetic reprogramming, germ cell development, and the overlap between germ cells, stem cells and cancer.
Assistant Professor of Biological Chemistry and Molecular Pharmacology
We combine structural biology, cell biology and biochemical reconstitutions to address the molecular workings of multi-protein ubiquitin ligase complexes. In particular, we are interested in protein complexes and pathways that contribute to the control of gene expression and are frequently associated with human disease and cancer.
Dean for Graduate Education, Professor of Biological Chemistry and Molecular Pharmacology
Our goals are to understand the molecular interactions controlling protein and lipid mobility and distribution in cell membranes, the roles these mechanisms play in interactions between cells, and the relationships between derangements in these mechanisms and the pathophysiology of disease.
Nancy Lurie Marks Professor of Biological Chemistry and Molecular Pharmacology in the Field of Medical Oncology
Our lab is interested in the following general questions: 1. How can small molecule inhibitors with selectivity towards a desired wild-type or drug-resistant kinase be efficiently developed? 2. How can we use kinase inhibitors to dissect the molecular wiring of signaling pathways? 3. What are the most efficient ways to develop small molecule modulators for protein targets for which no ligand is currently known? 4. How do you develop a small molecule modulator for biological pathways for which very little is known? 5.