HMS placeholder

Dominic M. Walsh, Ph.D.

Lecturer on Neurology
Publications View
A vicious cycle of ß amyloid-dependent neuronal hyperactivation.
Authors: Authors: Zott B, Simon MM, Hong W, Unger F, Chen-Engerer HJ, Frosch MP, Sakmann B, Walsh DM, Konnerth A.
Science
View full abstract on Pubmed
Target engagement in an alzheimer trial: Crenezumab lowers amyloid ß oligomers in cerebrospinal fluid.
Authors: Authors: Yang T, Dang Y, Ostaszewski B, Mengel D, Steffen V, Rabe C, Bittner T, Walsh DM, Selkoe DJ.
Ann Neurol
View full abstract on Pubmed
Soluble tau aggregates inhibit synaptic long-term depression and amyloid ß-facilitated LTD in vivo.
Authors: Authors: Ondrejcak T, Hu NW, Qi Y, Klyubin I, Corbett GT, Fraser G, Perkinton MS, Walsh DM, Billinton A, Rowan MJ.
Neurobiol Dis
View full abstract on Pubmed
Identification of neurotoxic cross-linked amyloid-ß dimers in the Alzheimer's brain.
Authors: Authors: Brinkmalm G, Hong W, Wang Z, Liu W, O'Malley TT, Sun X, Frosch MP, Selkoe DJ, Portelius E, Zetterberg H, Blennow K, Walsh DM.
Brain
View full abstract on Pubmed
PrP-grafted antibodies bind certain amyloid ß-protein aggregates, but do not prevent toxicity.
Authors: Authors: Mengel D, Hong W, Corbett GT, Liu W, DeSousa A, Solforosi L, Fang C, Frosch MP, Collinge J, Harris DA, Walsh DM.
Brain Res
View full abstract on Pubmed
Learnings about the complexity of extracellular tau aid development of a blood-based screen for Alzheimer's disease.
Authors: Authors: Chen Z, Mengel D, Keshavan A, Rissman RA, Billinton A, Perkinton M, Percival-Alwyn J, Schultz A, Properzi M, Johnson K, Selkoe DJ, Sperling RA, Patel P, Zetterberg H, Galasko D, Schott JM, Walsh DM.
Alzheimers Dement
View full abstract on Pubmed
Cellular Prion Protein Mediates the Disruption of Hippocampal Synaptic Plasticity by Soluble Tau In Vivo.
Authors: Authors: Ondrejcak T, Klyubin I, Corbett GT, Fraser G, Hong W, Mably AJ, Gardener M, Hammersley J, Perkinton MS, Billinton A, Walsh DM, Rowan MJ.
J Neurosci
View full abstract on Pubmed
Transmission of amyloid-ß protein pathology from cadaveric pituitary growth hormone.
Authors: Authors: Purro SA, Farrow MA, Linehan J, Nazari T, Thomas DX, Chen Z, Mengel D, Saito T, Saido T, Rudge P, Brandner S, Walsh DM, Collinge J.
Nature
View full abstract on Pubmed
MicroRNA-132 provides neuroprotection for tauopathies via multiple signaling pathways.
Authors: Authors: El Fatimy R, Li S, Chen Z, Mushannen T, Gongala S, Wei Z, Balu DT, Rabinovsky R, Cantlon A, Elkhal A, Selkoe DJ, Sonntag KC, Walsh DM, Krichevsky AM.
Acta Neuropathol
View full abstract on Pubmed
An in vitro paradigm to assess potential anti-Aß antibodies for Alzheimer's disease.
Authors: Authors: Jin M, O'Nuallain B, Hong W, Boyd J, Lagomarsino VN, O'Malley TT, Liu W, Vanderburg CR, Frosch MP, Young-Pearse T, Selkoe DJ, Walsh DM.
Nat Commun
View full abstract on Pubmed