Biological Chemistry & Molecular Pharmacology
Our primary research interest is to understand the molecular details of specialized, noncanonical mechanisms that regulate gene expression. Various proteins have evolved to act as specific modulators of genes in order to fine-tune their activity as well as to quickly respond to environmental cues. We focus on investigating the regulators that are directly involved in major human diseases such as cancer and diabetes. By employing biochemical and structural approaches, we not only aim to understand the molecular mechanism, but also to use the details provided by high-resolution structures for identifying potential therapeutic avenues. For appropriate candidate macromolecules we utilize computational techniques such as molecular dynamics and in silico docking to design small molecule inhibitors and to understand their interactions.
Our primary research interest is to understand the molecular details of specialized, noncanonical mechanisms that regulate gene expression.
Cell reports, March 14, 2017
Proceedings of the National Academy of Sciences of the United States of America, February 21, 2017
Structure (London, England : 1993), January 12, 2017
The American journal of pathology, November 12, 2016
Annals of the New York Academy of Sciences, November 10, 2016
Cell stem cell, June 16, 2016
Nature communications, March 7, 2016
Journal of the American Chemical Society, December 3, 2015
Cell, August 6, 2015
Structure (London, England : 1993), May 5, 2015