Latham Family Professor of Biological Chemistry and Molecular Pharmacology
We work on receptor-ligand interactions and signal transmission across membranes. We use a wide range of structural, cell biological, and single molecule techniques to answer important questions relevant to immunology, hemostasis, mammalian biology, and human disease.
David Wesley Gaiser Professor of Biological Chemistry and Molecular Pharmacology
We combine genetic, molecular, biochemical, genomic, and evolutionary approaches to study the mechanistic relationship between chromatin structure and transcriptional regulation and its implications for epigenetic inheritance of heterochromatin. In addition, we combine functional genomic and mechanistic approaches to elucidate the transcriptional regulatory circuits involved in the process of cellular transformation and formation of cancer stem cells, and the use of metformin as an anti-cancer drug in combination with chemotherapy.
Elkan Blout Professor of Biological Chemistry and Molecular Pharmacology
Our research is concerned with structures of proteins and protein complexes and their functional roles. We use NMR spectroscopy, other biophysical techniques, computational tools and small molecule inhibitors to reveal mechanisms and cellular significance of protein interactions.
Professor of Biological Chemistry and Molecular Pharmacology
Vertebrate cells employ intricate mechanisms to duplicate their genomes and guard against DNA damage. Xenopus laevis frog egg extracts have an extraordinary capacity to recapitulate these processes in the test tube, allowing us to elucidate the underlying mechanisms. Using this system, we study how the replicative DNA helicase unwinds DNA, how it is unloaded from chromatin during replication termination, and how its re-loading is prevented to limit replication to a single round per cell cycle.