Elkan Blout Professor of Biological Chemistry and Molecular Pharmacology
Our research is concerned with structures of proteins and protein complexes and their functional roles. We use NMR spectroscopy, other biophysical techniques, computational tools and small molecule inhibitors to reveal mechanisms and cellular significance of protein interactions.
Professor of Biological Chemistry and Molecular Pharmacology
Vertebrate cells employ intricate mechanisms to duplicate their genomes and guard against DNA damage. Xenopus laevis frog egg extracts have an extraordinary capacity to recapitulate these processes in the test tube, allowing us to elucidate the underlying mechanisms. Using this system, we study how the replicative DNA helicase unwinds DNA, how it is unloaded from chromatin during replication termination, and how its re-loading is prevented to limit replication to a single round per cell cycle.