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Caroline Shamu
Assistant Professor of Radiology

One of my main roles at Harvard Medical School is as Director of the ICCB-Longwood Screening Facility. ICCB-L supports both small molecule and RNAi screening, and was one of the first high throughput screening facilities established in an academic setting.

William Shih
Professor of Biological Chemistry and Molecular Pharmacology

We explore design principles for self-assembling molecular machines. As our model system, we primarily use structural DNA nanotechnology. We seek to apply our knowledge towards construction of artificial systems that help solve problems of biological and medical interest.

Piotr Sliz
Associate Professor of Pediatrics

Our primary research interest is to understand the molecular details of specialized, noncanonical mechanisms that regulate gene expression.

Timothy Springer
Latham Family Professor of Biological Chemistry and Molecular Pharmacology

We work on receptor-ligand interactions and signal transmission across membranes. We use a wide range of structural, cell biological, and single molecule techniques to answer important questions relevant to immunology, hemostasis, mammalian biology, and human disease.

Kevin Struhl
David Wesley Gaiser Professor of Biological Chemistry and Molecular Pharmacology

We combine genetic, molecular, biochemical, genomic, and evolutionary approaches to study the mechanistic relationship between chromatin structure and transcriptional regulation and its implications for epigenetic inheritance of heterochromatin.  In addition, we combine functional genomic and mechanistic approaches to elucidate the transcriptional regulatory circuits involved in the process of cellular transformation and formation of cancer stem cells, and the use of metformin as an anti-cancer drug in combination with chemotherapy.