One of my main roles at Harvard Medical School is as Director of the ICCB-Longwood Screening Facility. ICCB-L supports both small molecule and RNAi screening, and was one of the first high throughput screening facilities established in an academic setting.
Professor of Biological Chemistry and Molecular Pharmacology
We explore design principles for self-assembling molecular machines. As our model system, we primarily use structural DNA nanotechnology. We seek to apply our knowledge towards construction of artificial systems that help solve problems of biological and medical interest.
Latham Family Professor of Biological Chemistry and Molecular Pharmacology
We work on receptor-ligand interactions and signal transmission across membranes. We use a wide range of structural, cell biological, and single molecule techniques to answer important questions relevant to immunology, hemostasis, mammalian biology, and human disease.
David Wesley Gaiser Professor of Biological Chemistry and Molecular Pharmacology
We combine genetic, molecular, biochemical, genomic, and evolutionary approaches to study the mechanistic relationship between chromatin structure and transcriptional regulation and its implications for epigenetic inheritance of heterochromatin. In addition, we combine functional genomic and mechanistic approaches to elucidate the transcriptional regulatory circuits involved in the process of cellular transformation and formation of cancer stem cells, and the use of metformin as an anti-cancer drug in combination with chemotherapy.