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Karen Adelman
Professor of Biological Chemistry and Molecular Pharmacology

The Adelman laboratory investigates the dynamic interplay between signals from the environment and transcription by RNA polymerase II (Pol II).

Assistant Professor of Biological Chemistry and Molecular Pharmacology

We utilize a combination of techniques including NMR spectroscopy, NMR-based fragment and high throughput screening, and biophysical and cell-based assays to map hotspots in the interaction interface, to further understand the molecular mechanisms orchestrated by these interactions, and to identify disruptive inhibitors that may be developed into treatments for the related pathologies.